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生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
human
技術
flow cytometry: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... FPR2(2358)
相关类别
一般說明
Formyl peptide receptors (FPRs) are G protein coupled receptors critical for our immune response and the cellular activation and or suppression of immune cell activities. N-formyl peptides are produced by the degradation of either bacteria or host cells and serve as chemoattractant agents for white blood cells. There are three known formyl peptide receptors, FPR1, FPR2, and FPR3 all appear to have similar functions. Binding of N-formyl peptides activates neutrophils via the phosphatidylinositol-calcium second messenger system. In some cases binding leads to a down regulation of immune signals such as in the down regulation observed against the proinflammatory signaling agent leukotriene B4. Interestingly, FPRs also have endogenous ligands which appear to function in a developmental fashion and not directly as an immune function. For instance, FPR2’s endogenous ligand is a peptide named Cathelin-related antimicrobial peptide (CRAMP) which is critical for proper dendritic cell maturation. FRP2 is abundantly expressed in the lung, spleen and testis neutrophils. Because of their role in the immune cell activation, FPRs are also being investigated as possible targets for modulating immune caused diseases such as arthritis.
免疫原
Epitope: extracellular domain
KLH-conjugated linear peptide corresponding to the extracellular domain of human FPR2.
應用
Anti-FPR2 Antibody | ABF118 is an antibody against FPR2 Antibody for use in Western Blotting, Flow Cytometry.
Flow Cytometry Analysis: 1.0 µg of this antibody detected FPR2 in HL-60 cells.
Research Category
Inflammation & Immunology
Inflammation & Immunology
品質
Evaluated by Western Blotting in HL-60 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected FPR2 in 10 µg of HL-60 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected FPR2 in 10 µg of HL-60 cell lysate.
標靶描述
~45 kDa observed. The calculated molecular weight of this protein is 39 kDa, but can be observed at ~45 kDa due to high glycosylation.
外觀
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
其他說明
Concentration: Please refer to lot specific datasheet.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Rima Chattopadhyay et al.
Free radical biology & medicine, 117, 119-131 (2018-02-07)
In recent years, various studies have demonstrated a role for endogenously derived specialized proresolving mediators such as resolvins in the resolution of inflammation. In exploring the signaling mechanisms, in the present study we show that Resolvin D1 (RvD1) reduces LPS-induced
Rima Chattopadhyay et al.
Redox biology, 12, 438-455 (2017-03-21)
Resolvins are a novel class of lipid mediators that play an important role in the resolution of inflammation, although the underlying mechanisms are not very clear. To explore the anti-inflammatory mechanisms of resolvins, we have studied the effects of resolvin
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