AB5675-AF555

Anti-Metabotropic Glutamate Receptor 5 Antibody, Alexa Fluor^™ 555

from rabbit, ALEXA FLUOR^™ 555

• 别名: Metabotropic glutamate receptor 5, mGluR5, G protein-coupled receptor GRM5, G protein coupled receptor family C, group 1, member E
• UNSPSC代码: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物来源: rabbit
• 偶联物: ALEXA FLUOR^™ 555
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 种属反应性: rat
• 种属反应性（根据同源性预测）: bovine (based on 100% sequence homology), feline (based on 100% sequence homology), human (based on 100% sequence homology), primate (based on 100% sequence homology), horse (based on 100% sequence homology), mouse (based on 100% sequence homology)
• 技术: immunocytochemistry: suitable; immunofluorescence: suitable
• NCBI登记号: NP_001137306
• UniProt登记号: Q3UVX5
• 运输: wet ice
• 靶向翻译后修饰: unmodified
• 基因信息: human ... GRM5(2915)

说明

一般描述

Metabotropic glutamate receptor 5 or mGluR5 (UniProt P31424; also known as G protein-coupled receptor GRM5, G protein coupled receptor family C, group 1, member E) is encoded by the Grm5 (also known as Gprc1e, Mglur5) gene (Gene ID 24418) in rat species. The metabotropic glutamate receptors belong to a family of G protein-coupled receptors that have been divided into 3 groups based on their sequence homology, putative signal transduction mechanisms, and pharmacologic properties. mGluR1 and mGluR5 constitute Group I metabotropic glutamate receptors. mGluR5 is found on postsynaptic terminals of neurons and microglia. mGluR5 signals via Gq/G11 coupling to activate phospholipase C, resulting in calcium mobilization and activation of protein kinase C (PKC). In addition, mGluR5 is also reported to mediate signaling involving Src-family protein tyrosine kinase in a G protein-independent manner.

特异性

Expected to react with all spliced isoforms of human, rat, and mouse mGluR5 reported by UniProt (P41594, P31424 and Q3UVX5, respectively).

免疫原

Epitope: C-terminal cyoplasmic domain.

Synthetic peptide corresponding to a sequence from the C-terminal cytoplasmic domain of rat mGluR5.

应用

Anti-Metabotropic Glutamate Receptor 5 Antibody, Alexa Fluor^™ 555 is an antibody against Metabotropic Glutamate Receptor 5 for use in Immunocytochemistry, Immunofluorescence.

Immunocytochemistry Analysis: An 1:100 dilution from a representative lot detected Metabotropic Glutamate Receptor 5 in rat cortical neurons.
The unconjugated antibody (Cat. No. AB5675) is shown to be suitable also for Western blotting and immunohistochemistry applications.

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

质量

Evaluated by Immunofluorescence in rat brain tissue sections.

Immunofluorescence Analysis: An 1:100 dilution of this antibody detected Metabotropic Glutamate Receptor 5 in rat cerebellum, medulla, and brain tissue sections.

目标描述

~150 kDa observed.

外形

Affinity purified

Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

法律信息

ALEXA FLUOR is a trademark of Life Technologies

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable