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生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
mouse, human
物種活性（以同源性預測）
bovine (based on 100% sequence homology), porcine (based on 100% sequence homology), rat (based on 100% sequence homology)
技術
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... OPRM1(4988)
一般說明
μ阿片受体（MOP），也称为μ型阿片受体（MOR-1），是天然和合成阿片类药物的受体，例如β-内啡肽，内吗啡，吗啡，海洛因，DAMGO，芬太尼，埃托啡，丁丙诺啡和美沙酮。MOP充当A类G蛋白偶联受体（GPCR），但其下调途径随激动剂而变化，并且可能独立于也可能不独立于G蛋白偶联。与仅触发低脱敏和内吞作用的合成配体（如吗啡）相反，内源性配体诱导快速脱敏、内吞作用和再循环。与其他GPCR的异源寡聚化可以调节激动剂的结合，信号传导和运输特性。MOP在大脑中表达，并参与神经发生。MOP是大多数临床上重要的阿片类镇痛药的主要生理靶标。
特異性
该抗体可识别μ阿片受体的C端。该抗体可识别同工型1（45 kDa）、同工型10（55 kDa）、同工型12（34 kDa）和同工型13（36 kDa）。
免疫原
KLH偶联的线性肽，对应于人μ阿片受体的C端。
應用
使用经验证可用于蛋白质印迹 & IHC（石蜡）的兔多克隆抗体（抗μ阿片受体抗体）检测阿片受体。
免疫组化分析：代表性批次的1:1,000-4,000稀释液在人小脑、小鼠海马、小鼠中脑和大鼠中脑组织中检测到μ阿片受体。
品質
通过蛋白质印迹在SH-SY5Y细胞裂解液中进行了评估。
蛋白质印迹分析：0.2 µg/mL的该抗体在10 µg SH-SY5Y细胞裂解液中检测到μ阿片受体。
蛋白质印迹分析：0.2 µg/mL的该抗体在10 µg SH-SY5Y细胞裂解液中检测到μ阿片受体。
標靶描述
观测值〜70 kDa。计算的分子量为45 kDa，然而，μ阿片受体在蛋白质印迹中显示为~70-90 kDa的条带（Ferrer-Alcon, M., et al. (2004).Molecular Brain Research.121(1-2):114-122）。
聯結
替代品：AB1580
其他說明
浓度：请参考批次特异性浓缩物的检验报告。
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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