AB15242
Anti-zDHHC8 Antibody
from rabbit, purified by affinity chromatography
别名:
Zinc finger DHHC domain-containing protein 8, Zinc finger protein 378, membrane-associated DHHC8 zinc finger protein, zinc finger, DHHC domain containing 8, zinc finger, DHHC domain like containing 1, zinc finger, DHHC-type containing 8
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About This Item
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
价格与库存信息目前不能提供
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生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
rat, human
种属反应性（根据同源性预测）
horse, bovine, Xenopus, chicken, pig, chimpanzee, ape, opossum, mouse, dog
技术
western blot: suitable
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
chimpanzee ... Zdhhc8(458662)
human ... ZDHHC8(29801)
一般描述
Six genes in the 1.5 Mb region of chromosome 22 deleted in DiGeorge/22q11 deletion syndrome–Mrpl40, Prodh, Slc25a1, Txnrd2, T10, and Zdhhc8–encode mitochondrial proteins. All six genes are expressed in the
brain, and maximal expression coincides with peak forebrain synaptogenesis shortly after birth. Furthermore, their protein products are associated with brain mitochondria, including those in synaptic terminals. Among the six, only Zddhc8 influences mitochondria-regulated apoptosis when overexpressed, and appears to interact biochemically with established mitochondrial proteins. Zdhhc8 has an apparent interaction with Uqcrc1, a component of mitochondrial complex III. The two proteins are coincidently expressed in pre-synaptic processes; however, Zdhhc8 is more frequently seen in glutamatergic terminals (1).
brain, and maximal expression coincides with peak forebrain synaptogenesis shortly after birth. Furthermore, their protein products are associated with brain mitochondria, including those in synaptic terminals. Among the six, only Zddhc8 influences mitochondria-regulated apoptosis when overexpressed, and appears to interact biochemically with established mitochondrial proteins. Zdhhc8 has an apparent interaction with Uqcrc1, a component of mitochondrial complex III. The two proteins are coincidently expressed in pre-synaptic processes; however, Zdhhc8 is more frequently seen in glutamatergic terminals (1).
特异性
Cat. AB15242 recognizes the C-terminus of zDHHC8.
免疫原
Epitope: C-Terminus
Syntheic linear peptide.
应用
Anti-zDHHC8 Antibody is an antibody against zDHHC8 for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
质量
Routinely evaluated by western blot in fetal human brain lysate.
目标描述
~71 kDa
外形
ImmunoAffinity Purified
Purified in PBS with 0.05% NaN3
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
分析说明
Control
Fetal human brain
Fetal human brain
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Francisco S Mesquita et al.
Developmental cell, 56(20), 2790-2807 (2021-10-03)
SARS-CoV-2 virions are surrounded by a lipid bilayer that contains membrane proteins such as spike, responsible for target-cell binding and virus fusion. We found that during SARS-CoV-2 infection, spike becomes lipid modified, through the sequential action of the S-acyltransferases ZDHHC20
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