676490

VEGFR2_D1-7, Human, Recombinant, S. frugiperda

• 别名: Vascular Endothelial Growth Factor Receptor 2 _D1-7, Soluble KDR/Flk-1
• UNSPSC代码: 12352202
• NACRES: NA.77

属性

• 方案: ≥90% (SDS-PAGE)
• 质量水平: 100
• 表单: lyophilized
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze
• 溶解性: aqueous buffer: ≥100 μg/mL; water: ≥100 μg/mL
• 运输: wet ice
• 储存温度: −70°C

说明

一般描述

Recombinant, human VEGFR-2 consisting of all 7 immunoglobulin-like extracellular domains, but lacking the single transmembrane region and the intracellular split tyrosine kinase domain expressed in S. frugiperda insect cells. Contains all of the domains necessary for high affinity binding to VEGF. VEGFR-2 has a lower affinity for VEGF165 than VEGFR-1. However, VEGFR-2 has a higher signaling activity and is reported to mediate almost all observed endothelial cell responses to VEGF, including the increased microvascular permeability and endothelial cell proliferation. VEGFR-2 requires heparin for binding VEGF165.

生化/生理作用

Measured by the ability to inhibit VEGF165-induced proliferation in human umbilical vein endothelial (HUVE) cells

警告

Toxicity: Standard Handling (A)

外形

Lyophilized from 100 mM NaCl, 25 mM MES, pH 5.5.

重悬

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C. Avoid freeze/thaw cycles of solutions.

其他说明

Robinson, C.J., and Stringer, S.E. 2001 J. Cell Sci.114, 853.
Roeckl, W., et al. 1998. Exp. Cell Res.241, 161.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable