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Merck
所有图片(1)

主要文件

565792-M

Sigma-Aldrich

γ-Secretase Inhibitor XXIII, Aβ42-Selective

The γ-Secretase Inhibitor XXIII, Aβ42-Selective controls the biological activity of γ-Secretase.

别名:

γ-Secretase Inhibitor XXIII, Aβ42-Selective

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About This Item

经验公式(希尔记法):
C30H39N7O
分子量:
513.68
UNSPSC代码:
12352203
价格与库存信息目前不能提供

质量水平

方案

≥95% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

beige

溶解性

DMSO: 25 mg/mL

储存温度

2-8°C

一般描述

A cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC50 = 21 and 350 nM, respectively) and Notch1 (Notch IC50/ Aβ42 IC50 >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100 mg/kg, p.o.) in vivo.

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

其他说明

Rivkin, A., et al. 2010. Bioorg. Med. Chem. Lett.20, 2279.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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