565761

γ-Secretase Inhibitor IV

The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 别名: γ-Secretase Inhibitor IV, 2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
• 经验公式（希尔记法）: C₂₅H₂₆N₂O₃
• 分子量: 402.49
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥95% (HPLC)
• 表单: lyophilized solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: white
• 溶解性: DMSO: 10 mg/mL
• 运输: ambient
• 储存温度: −20°C

说明

一般描述

A cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβ_x-40 (ED₅₀ = 2.6 µM) and Aβ_x-42 (ED₅₀ = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.

生化/生理作用

Cell permeable: yes

ED50 = 2.6 µM for Aβx-40

Primary Target
Aβ_x-40

Product does not compete with ATP.

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

2-Naphthoyl-Val-Phe-CHO

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Green, K.N., et al. 2002. J. Physiol.541.3, 1013.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable