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product name
Ru360, Ru360, is a cell-permeable oxygen-bridged dinuclear ruthenium amine complex. Binds to mitochondria with high affinity (Kd = 340 pM) and blocks Ca2+ uptake into mitochondria in vitro (IC₅₀ = 184 pM).
品質等級
化驗
≥97%
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
protect from light
顏色
green
溶解度
deoxygenated water: 0.5 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
一般說明
一种可渗透性氧桥联双核钌胺络合物，已显示出与线粒体结合的高亲和力 (Kd = 0.34 nM)并可特异性阻断Ca2+在体外（IC50 = 184 pM）线粒体中和在原位完整心肌细胞中的摄取（在~10 µM的Ru360中孵育30分钟后完全阻断。即使在微摩尔水平下也不会影响参与心肌收缩的其他细胞Ca2+转运过程。
一种细胞渗透性氧桥联双核钌胺络合物，已显示出与线粒体结合的高亲和力 (Kd = 340 pM)。特异性阻断Ca2+在体外（IC50 = 184 pM）线粒体中和在原位完整心肌细胞中的摄取（在~10 µM的Ru360中孵育30分钟后完全阻断）。即使在微摩尔水平下也不会影响参与心肌收缩的其他细胞Ca2+转运过程。
注意：1组 = 10 x 100 µg.
生化／生理作用
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标IC50：184 pM 阻断Ca2+在体外摄取至线粒体中；以及在原位完整心肌细胞中；结合线粒体的Kd = 340 pM
首要靶标
Ca2+在体外摄取至线粒体中
Ca2+在体外摄取至线粒体中
包裝
用惰性气体包装
警告
毒性：标准处理（A）
重構
溶液中不稳定；仅在使用前进行重悬。
其他說明
Sanchez, J.A., et al. 2001.J. Physiol. 536, 387.
Bassani, R.A., et al. 1998.Cell Calcium23, 433.
Matlib, M.A., et al. 1998.J. Biol. Chem.273, 10223.
Zhou, Z., et al. 1998.J. Physiol.507 (pt 2), 379.
Emerson, J., et al. 1993.J. Am. Chem. Soc.115, 11799.
Ying, W.-L., et al. 1991.Biochemistry30, 4949.
Bassani, R.A., et al. 1998.Cell Calcium23, 433.
Matlib, M.A., et al. 1998.J. Biol. Chem.273, 10223.
Zhou, Z., et al. 1998.J. Physiol.507 (pt 2), 379.
Emerson, J., et al. 1993.J. Am. Chem. Soc.115, 11799.
Ying, W.-L., et al. 1991.Biochemistry30, 4949.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
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