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Merck
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文件

553525

Sigma-Aldrich

RAD51 Inhibitor, B02

The RAD51 Inhibitor, B02 controls the biological activity of RAD51. This small molecule/inhibitor is primarily used for Cell Structure applications.

别名:

RAD51 Inhibitor, B02, ( E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one

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About This Item

经验公式（希尔记法）:
C22H17N3O
CAS号:
1290541-46-6
分子量:
339.39
MDL號碼:
MFCD03294274
分類程式碼代碼:
12352200
NACRES:
NA.28

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

light yellow

溶解度

DMSO: 50 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

InChI

1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+

InChI 密鑰

GEKDQXSPTHHANP-OUKQBFOZSA-N

一般說明

A cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50 = 27.4 µM). Does not affect RecA even at much higher concentration (~250 µM). Directly interacts with RAD51 (Kd = 5.6 µM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin (Cat. No. 232120) and Mitomycin C (Cat. No. 47589), (Cat. No. 475820). Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 (Cat. No. 553510) is also available.

包裝

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Huang, F., et al. 2012. J. Med. Chem.55, 3031.
Huang, F., et al. 2011. ACS Chem. Biol.6, 628.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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