538925

Prostaglandin I₂, Sodium Salt

Potent vasodilatory prostaglandin produced by the endothelium.

• 别名: Prostaglandin I₂, Sodium Salt, PGI₂, Prostacyclin
• 经验公式（希尔记法）: C₂₀H₃₁O₅ · Na
• CAS号: 61849-14-7
• 分子量: 374.45
• 分類程式碼代碼: 12352211

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: crystalline solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 溶解度: water: soluble
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• InChI: 1S/C20H32O5.Na/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22;/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,15-8-;/t14-,16+,17+,18+,19-;/m0./s1
• InChI 密鑰: LMHIPJMTZHDKEW-XQYLJSSYSA-M

说明

一般說明

Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Cytoprotective and fibrinolytic. Inhibits platelet aggregation by receptor mediated stimulation of adenylate cyclase.

Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Exhibits cytoprotective and fibrinolytic properties.

生化／生理作用

Cell permeable: no

Primary Target
Induces vasodilation

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful (C)

重構

Following reconstitution, aliquot and freeze (-20°C). This product is rapidly hydrolyzed in acidic solutions. The half-life at pH 7.48 is between 3.5 min and 10.5 min at 25°C. At pH 12 the half-life is ~6 days at 25°C. No loss of biological activity was observed at pH 9.37 for 48 h, when stored at 0°C.

其他說明

Vane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res.15, 11.
Moncada, S., et al. 1979. Pharmacol. Rev.30, 293.
Cho, M.J. and Allen, M.A. 1978. Prostaglandins15, 943.
Tateson, J.E., et al. 1977. Prostaglandins13, 389.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable