5.32089

Dual DYRK/CLK inhibitor, Cpd 23

• 别名: Dual DYRK/CLK inhibitor, Cpd 23, Pre-mRNA Splicing Modulator, DYRK Inhibitor, Cdc2-like Kinase Inhibitor
• 经验公式（希尔记法）: C₁₀H₈O₂S
• CAS号: 56363-81-6
• 分子量: 192.23
• MDL编号: MFCD24717135
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥95% (HPLC)
• 质量水平: 100
• 表单: powder
• 效能: 60 nM IC₅₀
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: yellow
• 溶解性: DMSO: 50 mg/mL
• 储存温度: −20°C
• SMILES字符串: O=C(C)C1=CC2=CC(O)=CC=C2S1

说明

一般描述

A cell permeable 5-hydroxybenzothiophenylethanone that acts as a dual inhibitor of Cdc2-like kinase 1 (Clk1; IC₅₀ = 60 nM) and dual specificity tyrosine phosphorylation-regulated kinases 1A/1B (Dyrk1A/1B; IC₅₀ = 200 and 100 nM, respectively). Also inhibits Clk4 with high potency. Exhibits much reduced inhibitory effect on Haspin ( IC₅₀ = 800 nM) and has much reduced inhibitory effect on other kinases even at higher concentration (~ 5 µM). Causes a complete disappearance of incomplete and alternatively spliced transcripts and is shown to enhance the generation of the mature Clk1 mRNA splicing product (EC₅₀ = 8.9 µM) in cells.

A cell permeable, dual inhibitor of Cdc2-like kinase 1 (Clk1; IC₅₀ = 60 nM) and dual specificity tyrosine phosphorylation-regulated kinases 1A/1B (Dyrk1A/1B; IC₅₀ = 200 and 100 nM, respectively).

生化/生理作用

Cell permeable: yes

Primary Target
DYRK/CLK

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Schmitt, C., et al. 2014. ACS Med. Chem. Lett.5, 963.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable