跳转至内容
Merck
所有图片(1)

主要文件

5.08410

Sigma-Aldrich

Glycogen Phosphorylase Inhibitor II, KB228

别名:

Glycogen Phosphorylase Inhibitor II, KB228, KB-228

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C16H22N2O7
CAS号:
1595277-35-2
分子量:
354.36
分類程式碼代碼:
51111800
NACRES:
NA.77

化驗

≥98% (HPLC)

品質等級

100

形狀

powder

效力

930 nM Ki

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 100 mg/mL

儲存溫度

−20°C

一般說明

A glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (Ki = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.
A glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (Ki = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化／生理作用

Cell permeable: yes
Primary Target
Glycogen Phosphorylase
Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Nagy, L., et al. 2013. PLoS One.8, e69420.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Lilla Nagy et al.
PloS one, 8(7), e69420-e69420 (2013-08-13)
Glycogen phosphorylase (GP) catalyzes the breakdown of glycogen and largely contributes to hepatic glucose production making GP inhibition an attractive target to modulate glucose levels in diabetes. Hereby we present the metabolic effects of a novel, potent, glucose-based GP inhibitor

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门