5.05855

Adenovirus Proteinase Inhibitor

powder, ≥90% (HPLC)

• 别名: Adenovirus Proteinase Inhibitor, NSC 37249, 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide, AVP Inhibitor, AVP Inhibitor, 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide
• 经验公式（希尔记法）: C₄₀H₅₈N₄O₄S
• CAS号: 2907-88-2
• 分子量: 690.98
• MDL號碼: MFCD31800417
• 分類程式碼代碼: 12352202
• NACRES: NA.21

属性

• 产品名称: Adenovirus Proteinase Inhibitor, NSC 37249,
• 化驗: ≥90% (HPLC)
• 品質等級: 100
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: 5% TFA in ethanol: 5 mg/mL; DMSO: insoluble
• 儲存溫度: 2-8°C
• SMILES 字串: [S](=O)(=O)(c4ccc(cc4)NC(=O)CN(C6CCCCC6)C5CCCCC5)c1ccc(cc1)NC(=O)CN(C3CCCCC3)C2CCCCC2
• InChI: 1S/C40H58N4O4S/c45-39(29-43(33-13-5-1-6-14-33)34-15-7-2-8-16-34)41-31-21-25-37(26-22-31)49(47,48)38-27-23-32(24-28-38)42-40(46)30-44(35-17-9-3-10-18-35)36-19-11-4-12-20-36/h21-28,33-36H,1-20,29-30H2,(H,41,45)(H,42,46)
• InChI 密鑰: JQYJJPSTWWRURQ-UHFFFAOYSA-N

说明

一般說明

A sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus AVP, the cysteine proteinase critical for virion assembly and maturation, by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (K_i = 150 nM) and AVP-pVIc substrate-binding site (K_i = 400 nM), blocking not only AVP-pVIc active complex formation/AVP activation (IC₅₀ = 140 nM; [substrate] = 5 µM & [pVIc] = 40 µM), but also AVP-pVIc active complex catalytic activity (IC₅₀ = 490 nM; [substrate] = 5 µM). Does not affect the activity of the serine protease trypsin or the cysteine protease papain even at concentrations as high as 10 µM.

A sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus cysteine proteinase AVP by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (K_i = 150 nM) and AVP-pVIc substrate-binding site (K_i = 400 nM), blocking both AVP-pVIc active complex formation (IC₅₀ = 140 nM; [substrate] = 5 µM & [pVIc] = 40 µM) and catalytic activity (IC₅₀ = 490 nM; [substrate] = 5 µM) without affecting trypsin or papain protease activity even at concentrations as high as 10 µM.

生化／生理作用

Primary Target
AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket

Reversible: yes

Secondary Target
AVP-pVIc substrate-binding site

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

McGrath, W.J., et al. 2013. FEBS Lett.587, 2332.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable