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Merck
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主要文件

5.00469

Sigma-Aldrich

S107

≥98% (HPLC), solid, RyR-Calstabin interaction stabilizer, Calbiochem®

别名:

RyR-Calstabin Interaction Stabilizer, S107, 7-methoxy-4-methyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine, Ryanodine Receptor Stabilizer, Rycal S107

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About This Item

经验公式(希尔记法):
C11H15NOS
分子量:
209.31
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77
价格与库存信息目前不能提供

产品名称

RyR-Calstabin Interaction Stabilizer, S107,

化驗

≥98% (HPLC)

品質等級

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

off-white

溶解度

DMSO: 100 mg/mL

儲存溫度

2-8°C

SMILES 字串

S1CCN(Cc2c1ccc(c2)OC)C

InChI 密鑰

BGVCEGVSQDOGSB-UHFFFAOYSA-N

一般說明

RyR-Calstabin Interaction Stabilizer, S107 can protect hippocampal neurons from GABAergic synaptic changes caused by Abeta42 oligomers.[1]

應用

RyR-Calstabin Interaction Stabilizer, S107 has been used in culture media for hypoxic exposures to study the impact of hypoxia on sarcoplasmic reticulum calcium leakage and expression of ryanodine receptor2 (RyR2).[2]

生化/生理作用

Primary Target
RyR2

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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The ryanodine receptor-calstabin interaction stabilizer S107 protects hippocampal neurons from GABAergic synaptic alterations induced by Abeta42 oligomers
Hidisoglu E, et al.
The Journal of Physiology, 600(24), 5295-5309 (2022)
Hypoxia-Induced Sarcoplasmic Reticulum Ca2+ Leak Is Reversed by Ryanodine Receptor Stabilizer JTV-519 in HL-1 Cardiomyocytes
Trinh MD, et al.
Anatolian journal of cardiology, 26(6), 476-476 (2022)

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