495624

Olomoucine

InSolution, ≥98%, potent and selective inhibitor of p34cdc2/cyclin B and related kinases

• 别名: InSolution Olomoucine
• 经验公式（希尔记法）: C₁₅H₁₈N₆O
• 分子量: 298.34
• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: liquid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic); protect from light
• 运输: wet ice
• 储存温度: 2-8°C

说明

一般描述

A purine derivative that acts as a potent and selective inhibitor of p34cdc2/cyclin B (IC₅₀ = 7 µM) and related kinases, including p33cdk2/cyclin A (IC₅₀ = 7 µM), p33cdk2/cyclin E (IC₅₀ = 7 µM), p33cdk5/p35 (IC₅₀ = 3 µM), and p44MAPK (IC₅₀ = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D1 (IC₅₀ >1 mM) and p40cdk6/cyclin D3 (IC₅₀ >250 µM). Does not significantly affect the activity of other protein kinases even at 1 mM concentrations. Known to inhibit DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G₁ arrest similar to that observed in interleukin-2 deprived cells. Also used to synchronize cells in G₁.

生化/生理作用

Cell permeable: no

Primary Target
p34^cdk1/cyclin B

Product competes with ATP.

Reversible: yes

Target IC₅₀: 100 nM-100 µM against p34cdk1/cyclin B

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495620) in DMSO.

重悬

Following initial use, aliquot and refrigerate (4°C).

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 2
• 闪点(°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• 闪点(°C): 87 °C - closed cup - (Dimethylsulfoxide)