410960

Ischemin

A cell-permeable azobenzene compound that reversibly targets CBP-BRD acetyl-lysine binding pocket with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B.

• 别名: Ischemin, (E)-5-(2-Amino-4-hydroxy-5-methyl-phenylazo)-2,4-dimethyl-benzenesulfonic acid, MS120, BRD4 Inhibitor II
• 经验公式（希尔记法）: C₁₅H₁₇N₃O₄S
• CAS号: 1357059-00-7
• 分子量: 335.38
• MDL编号: MFCD28044303
• UNSPSC代码: 12352200
• NACRES: NA.51

属性

• 质量水平: 100
• 方案: ≥99% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: orange-red
• 溶解性: DMSO: 50 mg/mL, orange
• 运输: ambient
• 储存温度: 2-8°C
• SMILES字符串: CC1=C(/N=N/C2=C(N)C=C(O)C(C)=C2)C=C(C(C)=C1)S(=O)(O)=O
• InChI key: UUECJWRVDTUDCB-ISLYRVAYSA-N

说明

一般描述

A cell-permeable azobenzene compound that reversibly targets CREB-binding protein bromodomain (CBP-BRD) acetyl-lysine binding pocket (K_d = 19 µM) with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B (K_d = 37, 41, 70 and >100 µM, respectively) and disrupts CBP interaction with the binding partners. Blocks CBP-p53 interaction and alters the post-translational modification states on p53 and histones. Shown to inhibit the transcription functions of p53 on DNA damage (IC₅₀ = 5 µM for p53-induced p21 activation in Luc-U2OS cells) and suppress cardiac myocyte apoptosis during ischemia conditions.

包装

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

其他说明

Borah, J.C., et al. 2011, Chem. Biol.18, 531.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable