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化驗
≥95% (SDS-PAGE)
品質等級
形狀
liquid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
avoid repeated freeze/thaw cycles
溶解度
water: soluble
Protein ID登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−70°C
基因資訊
mouse ... Ifng(15978)
一般說明
Note: 1 KU = 1000 units.
Research area: Immunology and Cytokines
Recombinant, mouse γ-interferon, consisting of 134 amino acids, expressed in E. coli as a single, non-glycosylated polypeptide.
Recombinant, mouse γ-interferon, consisting of 134 amino acids, expressed in E. coli as a single, non-glycosylated polypeptide.
應用
γ-Interferon has been used to assess the response of wild-type and cytosolic phospholipase A2 (cPLA2)-deficient cells to IFN-mediated signals. It has also been used to study the signaling pathway associated with IFN-γ and to explore the potential role of β-Arrestin1 in the dephosphorylation of signal transducer and activator of transcription 1 (STAT1).
生化／生理作用
Interferon-gamma (IFN-γ), a proinflammatory cytokine, exhibits a significant impact on innate and adaptive immunity in terms of combatting intracellular infections and facilitating tumor control. It has a significant impact on various immunological pathways. IFN-γ influences the following biological processes:
Antigen Processing and Presentation: IFN-γ enhances the expression of molecules involved in antigen presentation. This helps in the efficient activation of T cells, leading to the initiation of adaptive immunity.
Reactive Oxygen Species (ROS): IFN-γ stimulates the production of ROS by promoting the assembly of NADPH oxidase subunits. These ROS possess strong microbicidal effects, aiding in the defense against invading pathogens.
Autophagy: IFN-γ induces the expression of proteins involved in autophagy, facilitating the clearance of intracellular pathogens and contributing to immune defense.
Apoptosis: IFN-γ triggers apoptotic cell death by increasing the expression of molecules associated with the apoptotic pathway.
Cell Migration and Leukocyte Traffic: IFN-γ promotes the expression of chemokines and adhesion molecules, facilitating immune cell migration and contributing to the initiation of inflammatory responses.
Antiviral Mediators: By inducing the expression of various antiviral proteins, IFN-γ counteracts viral infections at multiple stages of the viral life cycle.
Antigen Processing and Presentation: IFN-γ enhances the expression of molecules involved in antigen presentation. This helps in the efficient activation of T cells, leading to the initiation of adaptive immunity.
Reactive Oxygen Species (ROS): IFN-γ stimulates the production of ROS by promoting the assembly of NADPH oxidase subunits. These ROS possess strong microbicidal effects, aiding in the defense against invading pathogens.
Autophagy: IFN-γ induces the expression of proteins involved in autophagy, facilitating the clearance of intracellular pathogens and contributing to immune defense.
Apoptosis: IFN-γ triggers apoptotic cell death by increasing the expression of molecules associated with the apoptotic pathway.
Cell Migration and Leukocyte Traffic: IFN-γ promotes the expression of chemokines and adhesion molecules, facilitating immune cell migration and contributing to the initiation of inflammatory responses.
Antiviral Mediators: By inducing the expression of various antiviral proteins, IFN-γ counteracts viral infections at multiple stages of the viral life cycle.
警告
Toxicity: Standard Handling (A)
外觀
In 10 mM PBS, pH 7.4.
準備報告
Dilute only in buffers containing protein such as 0.1% BSA.
重構
Following initial thaw, aliquot and freeze (-70°C).
其他說明
Zantl, N., et al. 1998. Infect. Immun. 66, 2300.
Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Interferon-gamma (IFN-?): Exploring its implications in infectious diseases
Kak G, et al.
Biomolecular Concepts, 64-79, 9(1)-9(1) (2018)
cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis
Vignola MJ, et al.
The Journal of Biological Chemistry, 285(28), 1625-1635 (2010)
Impact of interferon-? on hematopoiesis
Bruin AMD, et al.
Blood, 24(16), 2479-2486 (2014)
Pei-Ju Liu et al.
Journal of the American Society of Nephrology : JASN, 33(11), 1989-2007 (2022-11-01)
Myo1e is a nonmuscle motor protein enriched in podocytes. Mutations in <i>MYO1E</i> are associated with steroid-resistant nephrotic syndrome (SRNS). Most of the <i>MYO1E</i> variants identified by genomic sequencing have not been functionally characterized. Here, we set out to analyze two
Christin Pelzel et al.
Molecular cell, 50(1), 149-156 (2013-04-16)
Signal transducer and activator of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-γ (IFNγ) stimulation, which results in the expression of genes with antiproliferative and immunomodulatory functions. The inactivation of STAT1 occurs through tyrosine dephosphorylation by the tyrosine
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