351801

Glucose Transporter Inhibitor III, STF-31

The Glucose Transporter Inhibitor III, STF-31 controls the biological activity of Glucose Transporter.

• 别名: Glucose Transporter Inhibitor III, STF-31, STF-31
• 经验公式（希尔记法）: C₂₃H₂₅N₃O₃S
• 分子量: 423.53
• MDL编号: MFCD04153828
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥99% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: white
• 溶解性: DMSO: 50 mg/mL
• 运输: wet ice
• 储存温度: 2-8°C
• SMILES字符串: [S](=O)(=O)(NCc2ccc(cc2)C(=O)Nc3cnccc3)c1ccc(cc1)C(C)(C)C
• InChI key: NGQPRVWTFNBUHA-UHFFFAOYSA-N

说明

一般描述

A cell-permeable sulfonamide that selectively inhibits the growth of VHL-deficient renal cell carcinomas (RCCs) dose-dependently (0-5 µM) by directly targeting glucose transporter 1 (GLUT1), which is up-regulated by HIF (hypoxia-inducible factor) transcription factor in VHL-deficient cells. It elicits decreased oxidative phosphorylation associated with aerobic glycolysis and leads to necrosis, which is consistent with the effect induced by GLUT1 RNA interference. It does not bind to other glucose transporters, and does not inhibit a broad range of 50 tested kinases.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Chan, D., et al. 2011. Sci. Transl. Med.3, 94ra70.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H302
• 预防措施声明: P264 - P270 - P301 + P312 - P501
• 危险分类: Acute Tox. 4 Oral
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable