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Merck
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344930

Sigma-Aldrich

弗林蛋白酶抑制剂I

≥90% (HPLC), solid, furin inhibitor, Calbiochem®

别名:

弗林蛋白酶抑制剂I

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About This Item

经验公式（希尔记法）:
C34H66ClN11O5
分子量:
744.41
分類程式碼代碼:
12352200
NACRES:
NA.28

product name

弗林蛋白酶抑制剂I, Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.

品質等級

100

化驗

≥90% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated

顏色

off-white

溶解度

methanol: 1 mg/mL
DMSO: soluble

運輸包裝

ambient

儲存溫度

−20°C

一般說明

一种不可逆结合弗林蛋白酶催化位点并阻断其活性的肽基氯甲基酮。因此，它可以用作病毒糖蛋白的高度特异性裂解抑制剂和病毒复制的阻滞剂。据报道，弗林蛋白酶可以阻断MT5-MMP的脱落并阻止MT5-MMP的活化。完全抑制纯化的弗林蛋白酶或PACE4对Boc-RVRR-AMC（50 µM）的裂解。也抑制内皮素转化酶的活性，减少BACE（β-位点APP裂解酶）的前肽裂解。
一种结合弗林蛋白酶催化位点并阻断其活性的肽基氯甲基酮。因此，它可以用作病毒糖蛋白的高度特异性裂解抑制剂和病毒复制的阻滞剂。据报道，弗林蛋白酶可以阻断MT5-MMP的脱落并阻止MT5-MMP的活化。还显示可减少BACE（β-位点APP裂解酶）的前肽裂解。

生化／生理作用

主要靶标
病毒糖蛋白
产物不与ATP竞争。
可逆：否
细胞可渗透性：是

警告

毒性：标准处理（A）

序列

癸酰基-Arg-Val-Lys-Arg-CMK

外觀

作为三氟乙酸盐提供。

重構

复溶后，等分并冷冻（-20°C）。储备液可在-20°C最长稳定1个月。

其他說明

Sugrue, R.J., et al. 2001.J. Gen.Virol.82, 1375.
Wang, X., and Pei, D. 2001.J. Biol. Chem.276, 35953.
Capell, A., et al. 2000.J. Biol. Chem. 275, 30849.
Denault, J.B., et al. 1995.FEBS Lett.362, 276.
Denault, J.B., et al. 1995.J. Cardiovasc.Pharmacol.26, S47.
Garten, W., et al. 1994.Biochimie 76, 217.
Hallenberger, S., et al. 1992.Nature 360, 358.
Stieneke-Gröber, A., et al. 1992.EMBO J. 11, 2407.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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