The ERK Inhibitor III, also referenced under CAS 331656-92-9, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
A cell-permeable furanyl-nitroaminoguanidine ERK-binding (KD = ~13 µM) compound that acts as a substrate-, but not ATP-, site-targeting inhibitor of ERK. Selectively inhibits the EGF-stimulated cellular phosphorylation of ERK substrates Rsk-1 and Elk-1, but not that of ERK1/2 or the anisomycin-induced phosphorylation of the p38 substrate ATP-2 in HeLa cells.
A cell-permeable furanyl-nitroaminoguanidine ERK-binding (KD of ~13 µM) compound that acts as a substrate-, but not ATP-, site-targeting inhibitor of ERK. Selectively inhibits the EGF-stimulated cellular phosphorylation of ERK substrates Rsk-1 and Elk-1, but not that of ERK1/2 or the anisomycin-induced phosphorylation of the p38 substrate ATP-2 in HeLa cells.
生化／生理作用
Cell permeable: yes
KD = ~13 µM against ERK
Primary Target ERK
Product does not compete with ATP.
Reversible: no
包裝
Packaged under inert gas
警告
Toxicity: Irritant (B)
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他說明
Chen, F., et al. 2006. Bioorg. Med. Chem. Lett.16, 6281.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
