215900

Carbonic Anhydrase IX/XII Inhibitor

The Carbonic Anhydrase IX/XII Inhibitor controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

• 别名: Carbonic Anhydrase IX/XII Inhibitor, CAIX Inhibitor
• 经验公式（希尔记法）: C₁₃H₁₂N₄O₅S
• CAS号: 175014-68-3
• 分子量: 336.32
• MDL號碼: MFCD07097504
• 分類程式碼代碼: 12352200
• NACRES: NA.54

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(N(=O)=O)C=C2

说明

一般說明

A cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (K_i = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.

A cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (K_i = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.

包裝

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

其他說明

Pacchiano, F., et al. 2011. J Med Chem.54, 1896.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable