203987

Butein

A cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor.

• 别名: Butein, 2ʹ,4ʹ,3,4-Tetrahydroxychalcone
• 经验公式（希尔记法）: C₁₅H₁₂O₅
• CAS号: 487-52-5
• 分子量: 272.25
• MDL號碼: MFCD00017300
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow
• 溶解度: DMSO: 10 mg/mL; methanol: soluble
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
• InChI 密鑰: AYMYWHCQALZEGT-ORCRQEGFSA-N

说明

一般說明

A cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC₅₀ = 65 µM) and p60^c-src (IC₅₀ = 65 µM) The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase (GSH-RD) and rat liver glutathione S-transferase (GST; IC₅₀ = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells.

A cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC₅₀ = 65 µM) and p60^c-src (IC₅₀ = 65 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase and rat liver glutathione-S-transferase (IC₅₀ = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells.

生化／生理作用

Cell permeable: yes

Primary Target
Tyrosine kinase activity of the EGF receptor

Product competes with ATP.

Reversible: yes

Target IC₅₀: 65 µM against tyrosine kinase activity of the EGF receptor

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

其他說明

Howitz, K.T., et al. 2003. Nature425, 191.
Chan, S.C., et al. 1998. Planta Med.64, 153.
Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435.
Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047.
Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable