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BMS

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT.

• 别名: BMS, bis(2-Mercaptoethylsulfone)
• 经验公式（希尔记法）: C₄H₁₀O₂S₃
• CAS号: 145626-87-5
• 分子量: 186.32
• MDL编号: MFCD00467637
• UNSPSC代码: 12352128

属性

• 质量水平: 100
• 方案: ≥99% (titration)
• 表单: crystalline solid
• 反应适用性: reagent type: reductant
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze
• 颜色: white
• pKa: (1) 7.9, (2) 9.0
• 运输: ambient
• 储存温度: −20°C
• SMILES字符串: [S](=O)(=O)(CCS)CCS
• InChI: 1S/C4H10O2S3/c5-9(6,3-1-7)4-2-8/h7-8H,1-4H2
• InChI key: YWXCBLUCVBSYNJ-UHFFFAOYSA-N

说明

一般描述

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at pH 7 with BMS than with DTT. Has a pK_a of 7.9 and 9.0.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

制备说明

May require warming (40-45°C) to achieve complete solubilization in H₂O.

其他说明

Singh, R., et al. 1995. Methods Enzymol.251, 167.
Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem.22, 109.
Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem.58, 633.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable