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Merck
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文件

06-413

Sigma-Aldrich

Anti-NFκB p52 Antibody

Upstate®, from rabbit

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

using Protein A

物種活性

human

製造商/商標名

Upstate®

技術

immunoprecipitation (IP): suitable
western blot: suitable

同型

IgG

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... NFKB1(4790)

一般說明

The NFκB transcription factor was originally identified as a protein complex consisting of a 65 kDa DNA binding subunit and an associated 50 kDa protein. The 65 kDa subunit is functionally related to c-Rel p75 and Rel B p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino terminus of a precursor designated p105. A cDNA has been isolated that encodes an alternative DNA binding subunit of NFκB. It is synthesized as a 100 kDa protein that is expressed in a variety of cell types and, like p105, undergoes cleavage to generate its NFκB subunit, in this case a protein designated p52 (previously referred to as p49). In contrast to p50 derived from p105, p52 acts in synergy with p65 to stimulate the HIV enhancer in transiently transfected Jurkat cells.

特異性

Recognizes NFκB p52 and its precursor.

免疫原

KLH conjugated synthetic peptide (CYNPGLDGIIEYDDFK) contained within amino acids 4-19 of human NF κB, p52

應用

Detect NFκB p52 with Anti-NFκB p52 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP & WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

品質

routinely evaluated by immunoblot on RIPA lysates from Raji cells

標靶描述

52 kDa, and precursor (100 kDa)

外觀

Unpurified
Format: Purified
Protein A Purified immunoglobulin in in 0.1M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% NaN3 as a preservative.

儲存和穩定性

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

分析報告

Control
Raji cell lysate, Jurkat whole cell lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

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Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.
Luftig, M; Yasui, T; Soni, V; Kang, MS; Jacobson, N; Cahir-McFarland, E; Seed, B; Kieff, E
Proceedings of the National Academy of Sciences of the USA null
Beyond the enhanceosome: cluster of novel ?B sites downstream of the human IFN-? gene is essential for lipopolysaccharide-induced gene activation.
Goh, FG; Thomson, SJ; Krausgruber, T; Lanfrancotti, A; Copley, RR; Udalova, IA
Blood null
Down-regulation of Bcl-2 enhances estrogen apoptotic action in long-term estradiol-depleted ER(+) breast cancer cells.
R X-D Song, Z Zhang, G Mor, R J Santen
Apoptosis null
TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.
Saitoh, T; Nakayama, M; Nakano, H; Yagita, H; Yamamoto, N; Yamaoka, S
The Journal of Biological Chemistry null
Critical role of RelB serine 368 for dimerization and p100 stabilization.
Maier, HJ; Marienfeld, R; Wirth, T; Baumann, B
The Journal of Biological Chemistry null

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