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形狀
powder
包裝
pkg of 1 × 500 μg (880123P-500ug)
製造商／商標名
Avanti Research™ - A Croda Brand 880123P
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113]NC(CC[C@H](NC(C1=CC=C(NCC(C=N2)=NC3=C2N=C(N)NC3=O)C=C1)=O)C([O-])=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+]
一般說明
DSPE-PEG(5000) Folate is a conjugate of folic acid and amino-PEG-DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol).
生化／生理作用
Folate receptors are cellular surface markers for numerous solid tumors. DSPE-PEG-folate (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000]) incorporated into liposomes serves as a targeting ligand. Folate targeted drug delivery is useful in diagnosing and treating cancer and inflammatory diseases. Many molecules such as toxins (proteinaceous), immune stimulators and anti-cancer drugs can be delivered to folate receptor.
包裝
5 mL Amber Glass Screw Cap Vial (880123P-500ug)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery, 48-48 (2014)
Folate-targeted gadolinium-lipid-based nanoparticles as a bimodal contrast agent for tumor fluorescent and magnetic resonance imaging
Nakamura T, et al.
Biological & Pharmaceutical Bulletin, 37(4), 521-527 (2014)
Folate receptor-mediated drug targeting: from therapeutics to diagnostics
Hilgenbrink AR and Low PS
Journal of Pharmaceutical Sciences, 94(10), 2135-2146 (2005)
Zhaoyan Yang et al.
ACS applied materials & interfaces, 11(51), 47671-47679 (2019-10-22)
Lead halide perovskite nanocrystals (NCs) are promising optical materials in many fields. However, their poor moisture stability, significant toxicity, and difficulty to be further functionalized greatly hinder their applications in bioimaging. Here, a universal strategy is demonstrated by simply encapsulating
A Gabizon et al.
Bioconjugate chemistry, 10(2), 289-298 (1999-03-17)
Conjugates of three components, folic acid-poly(ethylene glycol)-distearoylphosphatidylethanolamine (FA-PEG-DSPE), derived from PEG with molecular masses of 2000 and 3350 Da were synthesized by a carbodiimide-mediated coupling of FA to H2N-PEG-DSPE. The conjugates were characterized by 1H NMR, MALDI-TOF, and HPLC analysis
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