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860818P

Avanti

17:0(2S-OH) Ceramide

Avanti Research™ - A Croda Brand 860818P, powder

别名:

N-(2′-(S)-hydroxyheptadecanoyl)-D-erythro-sphingosine

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About This Item

经验公式（希尔记法）:
C35H69NO4
CAS号:
1246298-47-4
分子量:
567.93
MDL编号:
MFCD22416674
UNSPSC代码:
12352211
NACRES:
NA.25
价格与库存信息目前不能提供

表单

powder

包装

pkg of 1 × 5 mg (860818P-5mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 860818P

脂质类型

sphingolipids

运输

dry ice

储存温度

−20°C

SMILES字符串

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@@H](O)CCCCCCCCCCCCCCC)=O)CO

InChI key

MBKBHFOACJJHAN-GTQKJTMESA-N

一般描述

Ceramides with 2-hydroxy fatty acids (hFA) group are mainly found in the epidermis.[1] 17:0(2S-OH) Ceramide is a unique ceramide containing 17C long chain base fatty acid (heptadecanoic acid)-with 2′-hydroxyl group in S configuration.[2]

生化/生理作用

Hydroxy fatty acids (hFA)-sphingolipids helps in cell signaling.[3] They also facilitate cell differentiation and apoptosis.[2] hFA-ceramides in epidermis helps in permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H leads to the development of neurological disorders such as leukodystrophy and spastic paraparesis in humans.[3] hFA-ceramides in the cell membrane are essential for PM02734 drug to exhibit its anti-tumor activity.[4]

包装

5 mL Amber Glass Screw Cap Vial (860818P-5mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids

WGK

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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2?-Hydroxy ceramide in membrane homeostasis and cell signaling
Kota V and Hama H
Advances in Biological Regulation, 54, 223-230 (2014)
Levels of SCS7/FA2H-mediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734
Herrero AB, et al.
Cancer research, 68(23), 9779-9787 (2008)
Venkatesh Kota et al.
Advances in biological regulation, 54, 223-230 (2013-10-22)
Ceramide is a precursor of complex sphingolipids and also plays important roles in cell signaling. With the advances in lipid analytical technologies, the structural diversity of ceramide species have become evident, and the complexity of cellular metabolism and function associated
Fatty acid 2-Hydroxylation in mammalian sphingolipid biology
Hama H, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1801(4), 405-414 (2010)
Hiroko Hama
Biochimica et biophysica acta, 1801(4), 405-414 (2009-12-23)
2-Hydroxy fatty acids (hFA) are important components of a subset of mammalian sphingolipids. The presence of hFA in sphingolipids is best described in the nervous system, epidermis, and kidney. However, the literature also indicates that various hFA-sphingolipids are present in
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