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形狀
powder
包裝
pkg of 1 × 1 mg (860657P-1mg)
pkg of 1 × 5 mg (860657P-5mg)
製造商／商標名
Avanti Research™ - A Croda Brand 860657P
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
OC[C@@](N)([H])[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
一般說明
鞘氨醇-d7是鞘氨醇的氘代衍生物。鞘氨醇是一种重要的生物活性鞘脂代谢产物。它是一种源自鞘磷脂的18碳氨基醇。鞘氨醇含有不饱和烃链。
應用
鞘氨醇-d7已被用作液相色谱-串联质谱法的内标，用于定量分析生物样品中的鞘脂。
生化／生理作用
鞘氨醇负调节细胞增殖并诱导凋亡。它具有调节磷脂酶，蛋白激酶，离子通道，大麻素受体1型（CB-1）受体和类固醇生成因子1（SF-1）受体活性的能力。鞘氨醇是用于合成乙酰胆碱的前体。
包裝
5 mL棕色玻璃螺旋盖小瓶（860657P-1mg）
5 mL棕色玻璃螺旋盖小瓶（860657P-5mg）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
the
Lipid Mediators and Their Metabolism in the Brain (2011)
Stephanie Schwalm et al.
The American journal of pathology, 187(11), 2413-2429 (2017-08-16)
Kidney fibrosis is a hallmark of chronic kidney disease and leads to extracellular matrix accumulation, organ scarring, and loss of kidney function. In this study, we investigated the role of sphingosine kinase-2 (SPHK2) on the progression of tubular fibrosis by
Iulia Zoicas et al.
Cells, 9(5) (2020-05-24)
Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tgfb)
Irina Alecu et al.
Journal of lipid research, 58(1), 60-71 (2016-11-23)
The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and pancreatic β-cells. Pathologically elevated 1-deoxySLs cause the inherited neuropathy, hereditary
Olivier Cuvillier
Biochimica et biophysica acta, 1585(2-3), 153-162 (2003-01-18)
The sphingolipid metabolites ceramide, sphingosine, and sphingosine 1-phosphate contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite sphingosine act as negative regulators of cell proliferation and promote apoptosis. Conversely, sphingosine 1-phosphate, formed by phosphorylation of sphingosine by a
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