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Merck
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主要文件

857370P

Avanti

VU0155056

Avanti Research™ - A Croda Brand 857370P, powder

别名:

N-(2-{4-[2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}ethyl)-2-naphthamide

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About This Item

经验公式（希尔记法）:
C25H26N4O2
CAS号:
1130067-18-3
分子量:
414.50
MDL编号:
MFCD00037705
UNSPSC代码:
12352211
NACRES:
NA.25
价格与库存信息目前不能提供

方案

>99% (TLC)

表单

powder

包装

pkg of 1 × 1 mg (857370P-1mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 857370P

脂质类型

bioactive lipids

运输

dry ice

储存温度

−20°C

相关类别

应用

VU0155056 has been used as a phospholipase D-1 (PLD1) inhibitor:
  • to study its role in regulated exocytosis[1]
  • to test bacterial and human PLD enzymes for specificity of inhibition[2]
  • in neuro-2a (N2a) cell culture and survival assay[3]

生化/生理作用

VU0155056 or N-(2-{4-[2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl ethyl)-2-naphthamide is a cell permeable phospholipase D (PLD) inhibitor. It inhibits both PLD1 and PLD2.[4]

包装

5 mL Amber Glass Screw Cap Vial (857370P-1mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids

WGK

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Aditya Kulkarni et al.
Chemical biology & drug design, 84(3), 270-281 (2014-03-20)
Phospholipase D enzymes cleave lipid substrates to produce phosphatidic acid, an important precursor for many essential cellular molecules. Phospholipase D is a target to modulate cancer-cell invasiveness. This study reports synthesis of a new class of phospholipase D inhibitors based
Michael A Kennedy et al.
PLoS genetics, 7(2), e1001299-e1001299 (2011-02-25)
During Alzheimer's Disease, sustained exposure to amyloid-β₄₂ oligomers perturbs metabolism of ether-linked glycerophospholipids defined by a saturated 16 carbon chain at the sn-1 position. The intraneuronal accumulation of 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (C16:0 PAF), but not its immediate precursor 1-O-hexadecyl-sn-glycerophosphocholine (C16:0 lyso-PAF), participates
Sarah McDavid et al.
PloS one, 9(10), e109203-e109203 (2014-10-03)
Butanol (C4H10OH) has been used both to dissect the molecular targets of alcohols/general anesthetics and to implicate phospholipase D (PLD) signaling in a variety of cellular functions including neurotransmitter and hormone exocytosis. Like other primary alcohols, 1-butanol is a substrate
Sarah A Scott et al.
Nature chemical biology, 5(2), 108-117 (2009-01-13)
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid. Phosphatidic acid participates in both G protein-coupled receptor and receptor tyrosine kinase signal transduction networks. The lack of potent and isoform-selective inhibitors
Tatiana P Rogasevskaia et al.
The Journal of biological chemistry, 290(48), 28683-28696 (2015-10-04)
There are a diversity of interpretations concerning the possible roles of phospholipase D and its biologically active product phosphatidic acid in the late, Ca(2+)-triggered steps of regulated exocytosis. To quantitatively address functional and molecular aspects of the involvement of phospholipase

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