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840030P

Avanti

06:0 PS

1,2-dihexanoyl-sn-glycero-3-phospho-L-serine (sodium salt), powder

别名:

PS(6:0/6:0)

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About This Item

经验公式（希尔记法）:
C18H33NO10PNa
CAS号:
321862-85-5
分子量:
477.42
UNSPSC代码:
51191904
NACRES:
NA.25
价格与库存信息目前不能提供

方案

>99% (TLC)

表单

powder

包装

pkg of 1 × 10 mg (840030P-10mg)
pkg of 1 × 25 mg (840030P-25mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 840030P

脂质类型

phospholipids
cardiolipins

运输

dry ice

储存温度

−20°C

SMILES字符串

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCC)=O)COC(CCCCC)=O.[Na+]

InChI

1S/C18H34NO10P.Na/c1-3-5-7-9-16(20)26-11-14(29-17(21)10-8-6-4-2)12-27-30(24,25)28-13-15(19)18(22)23;/h14-15H,3-13,19H2,1-2H3,(H,22,23)(H,24,25);/q;+1/p-1/t14-,15+;/m1./s1

InChI key

OPDYVXCKOQKYDZ-LIOBNPLQSA-M

相关类别

一般描述

Phosphatidylserine (PS) is an acidic phospholipid.[1] Approximately 15–33 mol% of PS is present in the inner leaflet of the plasma membrane.[2]

应用

06:0 PS may be used to study its effect on α-syn (α-synuclein) oligomerization by DA (dopamine)[3] and as a phospholipid substrate to determine the kinetic parameters for phospholipase C by chromogenic assay.[4] It has also been used in the preparation of phospholipid vesicles.[5]

生化/生理作用

Phosphatidylserine (PS) participates in several signaling pathways.[1] This membrane phospholipid controls the Akt (protein kinase B) phosphorylation process.[6]

包装

5 mL Clear Glass Sealed Ampule (840030P-10mg)
5 mL Clear Glass Sealed Ampule (840030P-25mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Analysis of complex lipidomes
Medical Applications of Mass Spectrometry, 223-249 (2008)
Akt-GSK3 beta Pro-survival Signaling Pathway in Cerebral Ischemic Injury
Primer on Kidney Diseases, Volume 953, 269-272 (2017)
Mingquan Guo et al.
Journal of molecular neuroscience : MN, 33(1), 67-73 (2007-09-29)
Phosphatidylserine (PS), the major acidic phospholipid class in eukaryotic biomembranes, plays an important role in various signaling pathways. We have previously demonstrated that docosahexaenoic acid (DHA, 22:6n-3) positively modulates PS biosynthesis and accumulation in neuronal cells, promoting survival. In this
Chi L L Pham et al.
Bioscience reports, 33(5) (2013-09-27)
The deposition of α-syn (α-synuclein) as amyloid fibrils and the selective loss of DA (dopamine) containing neurons in the substantia nigra are two key features of PD (Parkinson's disease). α-syn is a natively unfolded protein and adopts an α-helical conformation
Carolina Varela Chavez et al.
Cellular microbiology, 17(10), 1477-1493 (2015-04-18)
Clostridium sordellii lethal toxin (TcsL) is a potent virulence factor belonging to the large clostridial glucosylating toxin family. TcsL enters target cells via receptor-mediated endocytosis and delivers the N-terminal catalytic domain (TcsL-cat) into the cytosol upon an autoproteolytic process. TcsL-cat
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Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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