推荐产品
化驗
>99% (TLC)
形狀
liquid
包裝
pkg of 2 × 4 mL (800812C-200mg)
pkg of 1 × 5 mL (800812C-10mg)
製造商／商標名
Avanti Research™ - A Croda Brand 800812C
濃度
2 mg/mL (800812C-10mg)
25 mg/mL (800812C-200mg)
脂質類型
neutral lipids
neutral glycerides
運輸包裝
dry ice
儲存溫度
−20°C
InChI
1S/C27H52O5/c1-3-5-7-9-11-13-15-17-19-21-26(29)31-24-25(23-28)32-27(30)22-20-18-16-14-12-10-8-6-4-2/h25,28H,3-24H2,1-2H3/t25-/m0/s1
InChI 密鑰
OQQOAWVKVDAJOI-VWLOTQADSA-N
一般說明
sn-1,2-diacylglycerols comprise short saturated acyl side chains (C4-C10) and 12:0 DG is also called 1,2-dilauroyl-sn-glycerol.
應用
12:0 DG may be used:
- as an internal standard for spiking serum samples for liquid chromatography–mass spectrometry analysis.
- as an internal standard for spiking RAW 264.7 cells for mass spectroscopy studies
- as standard in reverse-phase liquid chromatography coupled mass spectrometer for lipidomics studies of human plasma and serum samples
生化／生理作用
sn-1,2-Diacylglycerols are prime regulators of biological functions, especially in platelets. They also activate protein kinase C. 1,2-dilauroyl-sn-glycerol is a polymerization initiator used in the synthesis of (R)-3-((2-bromo-2-methylpropanoyl)oxy)propane-1,2-diyl didodecanoate (BMPD).
包裝
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800812C-10mg)
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800812C-200mg)
儲存和穩定性
Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.
其他說明
Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
訊號詞
Danger
危險分類
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
標靶器官
Central nervous system, Liver,Kidney
儲存類別代碼
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
does not flash
閃點（°C）
does not flash
Exogenous sn-1, 2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.
Lapetina EG, et al.
The Journal of Biological Chemistry, 260(3), 1358-1361 (1985)
Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm
Callender HL, et al.
Analytical Chemistry, 79(1), 263-272 (2007)
Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation
Ebeling JG, et al.
Proceedings of the National Academy of Sciences of the USA, 82(3), 815-819 (1985)
Lipidated polymers for the stabilization of cubosomes: nanostructured drug delivery vehicles
Grace JL, et al.
Chemical Communications (Cambridge, England), 53(76), 10552-10555 (2017)
Lipid Profile Characterization and Lipoprotein Comparison of Extracellular Vesicles from Human Plasma and Serum
Sun Y, et al.
Metabolites, 9(11), 259-259 (2019)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门