方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 mg (800715P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 800715P
脂质类型
phosphoglycerides
运输
dry ice
储存温度
−20°C
一般描述
Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid is a competitive inhibitor of the LPA receptor in Xenopus oocytes.[1][2] However, in mammalian cells, N-palmitoyl-serine phosphoric acid may act as an agonist for the LPA receptor. [3][4] LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors.[1][2][3][4][5] LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation.[1] N-palmitoyl serine phosphoric acid may also play a role in signal transduction in mammalian cells by increasing intracellular calcium. [4][5]
N-palmitoyl serine phosphoric acid prevents human platelet aggregation, which is induced by 1-hexadecyl-2-lyso-sn-glycero-3-phosphate.[6]
包装
5 mL Amber Glass Screw Cap Vial (800715P-1mg)
制备说明
Product use: A range of 0.1-20 mM of N-palmitoyl serine phosphoric acid can be used for cell studies. Make a stock solution of 5 mM in DMSO and store at -20°C. Diluted N-palmitoyl serine phosphoric acid can be directly added to the study medium. [5]An et al. dissolved N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells.[4] In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection.[2]
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Characterization of a receptor subtype-selective lysophosphatidic acid mimetic
Hooks, S.B, et. al.
Molecular Pharmacology, 53, 188-194 (1998)
Chung-Ren Jan et al.
Pharmacology & toxicology, 93(2), 71-76 (2003-08-06)
The effect of N-palmitoyl-L-serine phosphoric acid (L-NASPA), which has been used as an inhibitor of lysophosphatidic acid receptors, on intracellular Ca2+ concentration ([Ca2+]i) in human osteosarcoma MG63 cells was measured by using fura-2. L-NASPA (0.1-10 microM) caused a rapid and
Novel effect of N-palmitoyl-L-serine phosphoric acid on cytosolic Ca2+ levels in human osteoblasts
Jan, C.R
Pharmacology & Toxicology, 93, 71-76 (2003)
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.
An, S
Molecular Pharmacology, 54, 881-888 (1998)
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids.
Bittman R, et al.
Journal of Lipid Research, 37(2), 391-398 (1996)
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