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化驗
>99% (TLC)
形狀
liquid
包裝
pkg of 1 × 1 mL (791647C-1mg)
製造商／商標名
Avanti Research™ - A Croda Brand 791647C
濃度
1 mg/mL (791647C-1mg)
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
15:0-18:1-d7 DG (1-pentadecanoyl-2-oleyol(d7)-sn-glycerol) is a deuterated derivative of 15:0-18:1-DG, with deuteration in the oleic acid bonded to glycerol in sn-2 position. Pentadecanoic is bonded to sn-1 position. Diacylglycerols (DAG) are neutral lipids that carry fatty acid esterification. DAG is synthesized from the catabolic cleavage of headgroups of phospholipids. It is a small lipid and is membrane-associated.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH™ LIPIDOMIX™ Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample.
應用
15:0-18:1-d7 DG (1-pentadecanoyl-2-oleyol(d7)-sn-glycerol) has been used:
- as an internal standard to spike skeletal muscle samples for liquid chromatography-mass spectroscopy (LC-MS) analysis
- as a lipid standard in mass spectroscopy for the identification of lipids in mitochondria and lipid droplets
- in the egg yolk lipid extraction as an internal standard for mass spectroscopy analysis
生化／生理作用
Diacylglycerols (DAG) are lipid messengers that participate in metabolic events. Altered levels, especially accumulation of DAG is implicated in insulin resistance. DAG serves as lipid modules for complex lipid synthesis. Protein kinase C (PKC) modulates DAG by interacting through its C1 domain. Impairment in DAG production is correlated to the pathology of Alzheimer′s disease, cancer and immune system diseases.
包裝
2 mL Amber Glass Sealed Ampule (791647C-1mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
LIPIDOMIX is a trademark of Avanti Polar Lipids, LLC
SPLASH is a trademark of Avanti Polar Lipids, LLC
也與該產品經常一起購買
产品编号
说明
价格
訊號詞
Danger
危險分類
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
標靶器官
Central nervous system, Liver,Kidney
儲存類別代碼
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
does not flash
閃點（°C）
does not flash
Thomas Oliver Eichmann et al.
Cellular and molecular life sciences : CMLS, 72(20), 3931-3952 (2015-07-15)
The neutral lipids diacylglycerols (DAGs) are involved in a plethora of metabolic pathways. They function as components of cellular membranes, as building blocks for glycero(phospho)lipids, and as lipid second messengers. Considering their central role in multiple metabolic processes and signaling
Silvia Carrasco et al.
Trends in biochemical sciences, 32(1), 27-36 (2006-12-13)
Diacylglycerol (DAG) has unique functions as a basic component of membranes, an intermediate in lipid metabolism and a key element in lipid-mediated signaling. In eukaryotes, for example, impaired DAG generation and/or consumption have severe effects on organ development and cell
Ya Xie et al.
Food chemistry, 319, 126547-126547 (2020-03-18)
In this research, a novel ultrasound-assisted extraction (USAE) method using a one-phase solvent (isopropanol, IPA) combined with liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry (LC-ESI-QToF-MS) was developed for exhaustive profiling of egg yolk lipids, which are considered to be essential
Paul T Reidy et al.
The Journal of physiology, 596(21), 5217-5236 (2018-09-09)
Insulin sensitivity (as determined by a hyperinsulinaemic-euglyceamic clamp) decreased 15% after reduced activity. Despite not fully returning to baseline physical activity levels, insulin sensitivity unexpectedly, rebounded above that recorded before 2 weeks of reduced physical activity by 14% after the recovery
Florian Geltinger et al.
GeroScience, 42(1), 19-38 (2019-11-05)
Originally Lipid droplets (LDs) were considered as being droplets for lipid storage only. Increasing evidence, however, demonstrates that LDs fulfill a pleiotropy of additional functions. Among them is the modulation of protein as well as lipid homeostasis. Under unfavorable pro-oxidative
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