Only the aldehyde content is determined by the titration with hydroxylamine. The location of the aldehyde groups is not determined and the image is representative.
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质量水平
描述
Degree of functionalization: 15-25%
表单
powder
颜色
white to off-white
适用性
conforms to structure for NMR
储存温度
2-8°C
SMILES字符串
CO[C@H]1[C@@H](O)[C@H](O)[C@H](O/C(C=O)=C\C([O-])=O)O[C@@H]1C([O-])=O.OC2[C@H](OC(O)C=O)[C@@H](C([O-])=O)O[C@@H](OC)[C@H]2O
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应用
Alginate is an anionic polysaccharide that is widely used in pharmaceutical and biomedical applications due to its non-animal origin, low toxicity, biocompatibility, and biodegradability[1]. Alginate hydrogels are commonly used to fabricate tissue engineering scaffolds[2], bioinks for 3D bioprinting[3][4], and nanocarriers for drug and gene delivery.
Alginate is commonly crosslinked into a hydrogel via ionic-crosslinking with divalent cations (e.g., Ca2+). To prevent matrix degradation, alginate can be functionalized with reactive groups that can be chemically crosslinked, such as aldehydes.[5] Aldehyde- functionalized alginate can be used to prepare hydrogels by reaction with amine groups, such as gelatin through Schiff-base reaction to form a chemical hydrogel. This material can be used in a variety of biomedical applications such as the delivery of drugs, cells, or biomolecules in different tissues, wound healing, and muscle and bone tissue engineering. [6]
Alginate is commonly crosslinked into a hydrogel via ionic-crosslinking with divalent cations (e.g., Ca2+). To prevent matrix degradation, alginate can be functionalized with reactive groups that can be chemically crosslinked, such as aldehydes.[5] Aldehyde- functionalized alginate can be used to prepare hydrogels by reaction with amine groups, such as gelatin through Schiff-base reaction to form a chemical hydrogel. This material can be used in a variety of biomedical applications such as the delivery of drugs, cells, or biomolecules in different tissues, wound healing, and muscle and bone tissue engineering. [6]
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
B Balakrishnan et al.
Carbohydrate research, 340(7), 1425-1429 (2005-04-28)
Periodate oxidation of sodium alginate in aqueous solution as well as a dispersion in 1:1 ethanol-water was examined. The oxidation proceeded smoothly in both media, and the kinetics of oxidation was surprisingly similar. Polymer cleavage was observed in both media
Biji Balakrishnan et al.
Biomaterials, 26(18), 3941-3951 (2005-01-01)
The injectable polymer scaffolds which are biocompatible and biodegradable are important biomaterials for tissue engineering and drug delivery. Hydrogels derived from natural proteins and polysaccharides are ideal scaffolds for tissue engineering since they resemble the extracellular matrices of the tissue
Controlling alginate oxidation conditions for making alginate-gelatin hydrogels
Emami Z, et al.
Carbohydrate Polymers, 198, 509-517 (2018)
The effect of oxidation on the degradation of photocrosslinkable alginate hydrogels
Jeon O, et al.
Biomaterials, 33(13), 3503-3514 (2012)
Supachai Reakasame et al.
Biomacromolecules, 19(1), 3-21 (2017-11-28)
Oxidized alginate (OA)-based hydrogels have drawn considerable attention as biodegradable materials for tissue engineering applications. OA possesses a faster degradation rate and contains more reactive groups compared to native alginate. This review summarizes the research publications reporting the development of
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Is the alginate aldehyde terminated, as described in the linear formula, with only 20% of the chains functionalized? Or is the backbone of the chain functionalized with aldehyde with 20% of the monomers containing aldehyde groups?
1 answer-
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