920517

6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid

• 别名: Rigid linker for PROTAC^® development
• 经验公式（希尔记法）: C₁₅H₂₂N₄O₄
• CAS号: 1700483-37-9
• 分子量: 322.36
• MDL编号: MFCD34602224
• UNSPSC代码: 12352106
• NACRES: NA.22

属性

• 反应适用性: reagent type: linker
• 质量水平: 100
• 官能团: Boc; carboxylic acid
• 储存温度: 2-8°C
• SMILES字符串: CC(C)(OC(N1CCCN(C2=CN=CC(C(O)=O)=N2)CC1)=O)C
• InChI: 1S/C15H22N4O4/c1-15(2,3)23-14(22)19-6-4-5-18(7-8-19)12-10-16-9-11(17-12)13(20)21/h9-10H,4-8H2,1-3H3,(H,20,21)
• InChI key: JBZILBWYLNAFOB-UHFFFAOYSA-N

说明

应用

6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920525
920681

其他说明

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable