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919012

Sigma-Aldrich

PEI Prime™线性聚乙烯亚胺

suitable for gene delivery

别名:

PEI

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100 MG
$420.00

$420.00

国内现货，预计发货时间2025年4月25日详情

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100 MG
$420.00

About This Item

线性分子式:
(C2H5N . HCl)n
CAS号:
49553-93-7
MDL编号:
MFCD00009361
UNSPSC代码:
12162002
NACRES:
NA.23

$420.00

国内现货，预计发货时间2025年4月25日详情

获取大包装报价

质量水平

100

表单

powder

颜色

white to off-white

储存温度

2-8°C

SMILES字符串

N(CCC)C

InChI

1S/C4H11N/c1-3-4-5-2/h5H,3-4H2,1-2H3

InChI key

GVWISOJSERXQBM-UHFFFAOYSA-N

相关类别

应用

PEI Prime ™是一种阳离子聚合物，设计用于高产、可重复和可放大的药物和基因递送。作为基因载体，PEI通过带负电的核酸磷酸基团和带正电的PEI胺基之间的静电自组装与核酸形成复合物。由于这种相互作用，PEI 作为基因载体被研究人员广泛研究，并且是通过内吞作用将核酸递送到细胞中的最有效的合成聚合物之一。


PEI Prime ™采用优化的 PEI 形式来减少性能差异并加快工艺开发时间。每批 PEI Prime ™都用 SEAP 报告基因进行三次重复的定量性能测试。PEI Prime ™是经济有效地生产任何生物制品（包括重组蛋白、抗体和病毒）的绝佳选择。

法律信息

PEI Prime is a trademark of Serochem LLC

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCW4935
MKCV6751
MKCT5539
MKCT0529
MKCV0804

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S M Zou et al.
The journal of gene medicine, 2(2), 128-134 (2000-05-16)
Several nonviral vectors including linear polyethylenimine (L-PEI) confer a pronounced lung tropism to plasmid DNA when injected into the mouse tail vein in a nonionic solution. and results We have optimized this route by injecting 50 microg DNA with excess
L Wightman et al.
The journal of gene medicine, 3(4), 362-372 (2001-09-01)
Efficient gene transfer is a major challenge for non-viral gene therapy. Understanding how non-viral vectors initiate gene expression could lead to the development of new future vectors with enhanced efficacy. Linear or branched polyethylenimine (PEI)/DNA complexes were generated in varying
W T Godbey et al.
Biomaterials, 22(5), 471-480 (2001-02-24)
Poly(ethylenimine) (PEI) was used to transfect the endothelial cell line EA.hy 926, and the secreted levels of three gene products, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand Factor (vWF), were assessed via ELISA. We

Questions

1–4 of 4 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. What is the Molecular weight of PEI Prime?

    1 answer

    1. The molecular weight of this product is not determined.

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  4. What is the Degree Polimerization?

    1 answer

    1. The degree of polymerization has not been determined for this product.

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