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914223

Sigma-Aldrich

Biotin-SLF

别名:

(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(4,18-dioxo-22-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-8,11,14-trioxa-5,17-diazadocosanamido)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate, Bio-SLF, Biotin-conjugated FKBP12WT-directed ligand, Biotin-conjugated SLF ligand, FKBP12WT affinity probe for PROTAC® and targeted protein degradation research

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5 MG
$1,030.00

$1,030.00

预计发货时间2025年6月02日详情

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5 MG
$1,030.00

About This Item

经验公式（希尔记法）:
C52H76N6O13S
CAS号:
2230857-85-7
分子量:
1025.26
MDL编号:
MFCD33021721
UNSPSC代码:
12352200
NACRES:
NA.22

$1,030.00

预计发货时间2025年6月02日详情

获取大包装报价

ligand

biotin

质量水平

100

表单

powder

储存温度

−20°C

SMILES字符串

O=C(CCC(NCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)=O)=O)NC3=CC([C@H](OC([C@@H]4CCCCN4C(C(C(C)(C)CC)=O)=O)=O)CCC5=CC=C(OC)C(OC)=C5)=CC=C3

InChI key

QFIMAWUXIBINCP-SLBVAARVSA-N

相关类别

应用

Biotin-SLF (bio-SLF) is an FKBP12WT affinity probe useful in chemical biology or targeted protein degradation where FKBP12 is used as a tool protein and its enrichment is required in discovery experiments or assay validation.


Related tools:
Additional bifunctional tools for FKPB12 variants:

  • dTAG-13 (SML2601) for FKBP12F36V; and KB02-SLF (914738), KB03-SLF (914975), and KB04-SLF (913715) for FKBP12WT
  • Cereblon (CRBN) affinity probe: Biotin-Thalidomide (913979)
Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

其他说明

The dTAG system for immediate and target-specific protein degradation

Technology Spotlight: Building PROTAC® Degraders for Targeted Protein Degradation

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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价格

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

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Behnam Nabet et al.
Nature chemical biology, 14(5), 431-441 (2018-03-28)
Dissection of complex biological systems requires target-specific control of the function or abundance of proteins. Genetic perturbations are limited by off-target effects, multicomponent complexity, and irreversibility. Most limiting is the requisite delay between modulation to experimental measurement. To enable the

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