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應用
当暴露于细胞或组织裂解物时,生物素化异恶唑 (b-isox) 可沉淀 RNA 结合蛋白,与 RNA 颗粒的成分有明显重叠。通过与 RNA 颗粒相似的可逆性聚集和解聚结构,b-isox 有助于洞察 RNA 结合蛋白可逆性聚集所必需的多肽。
本品之前被列为 T511617。
本品之前被列为 T511617。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains.
Cell, 155(5), 1049-1060 (2013)
Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies.
Cell, 149(4), 768-779 (2012)
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells.
Science (New York, N.Y.), 345(6201), 1139-1145 (2014-08-02)
Many RNA regulatory proteins controlling pre-messenger RNA splicing contain serine:arginine (SR) repeats. Here, we found that these SR domains bound hydrogel droplets composed of fibrous polymers of the low-complexity domain of heterogeneous ribonucleoprotein A2 (hnRNPA2). Hydrogel binding was reversed upon
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