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862169

Sigma-Aldrich

2-顺式,4-反式脱落酸

synthetic, 98%

别名:

脱落酸, (2Z,4E)-5-(1-羟基-2,6,6-三甲基-4-氧-2-环己烯-1-基)-3-甲基-2,4-戊二烯酸, ABA, 休眠素

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50 MG
$70.40
250 MG
$243.00

$70.40

国内现货，预计发货时间2025年4月08日详情

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50 MG
$70.40
250 MG
$243.00

About This Item

经验公式（希尔记法）:
C15H20O4
CAS号:
14375-45-2
分子量:
264.32
MDL编号:
MFCD00075619
UNSPSC代码:
12352100
PubChem化学物质编号:
24888569
NACRES:
NA.22

$70.40

国内现货，预计发货时间2025年4月08日详情

获取大包装报价

质量水平

100

方案

98%

表单

powder

mp

186-188 °C (lit.)

官能团

carboxylic acid
hydroxyl
ketone

储存温度

2-8°C

SMILES字符串

CC(\C=C\C1(O)C(C)=CC(=O)CC1(C)C)=C\C(O)=O

InChI

1S/C15H20O4/c1-10(7-13(17)18)5-6-15(19)11(2)8-12(16)9-14(15,3)4/h5-8,19H,9H2,1-4H3,(H,17,18)/b6-5+,10-7-

InChI key

JLIDBLDQVAYHNE-LXGGSRJLSA-N

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相关类别

一般描述

2-cis,4-trans-脱落酸(ABA)是一种有机物，用作有机合成的起始原料。也用作不对称合成中的手性助剂。ABA衍生物可作为手性模板诱导特定产物的生成，用于控制反应的立体化学性质。 [1]

应用


  • 脱落酸的手性分离：研究展示了使用苯基柱和γ-环糊精流动相的高效液相色谱法进行的脱落酸的直接手性分离，推动了植物应激激素研究所必需的分析方法的进步（Terashima et al., 2023）。

  • 黄嘌呤氧化酶抑制活性：一项涉及脱落酸衍生物的研究表明，黄嘌呤氧化酶具有显著的抑制活性，具有潜在的健康益处和治疗应用（Miyata et al., 2019）。

  • 抗癌潜力：来自红树林内生真菌的含脱落酸提取物具有细胞毒性特性，并诱导人癌症细胞的G（0）/G（1）细胞周期停滞和凋亡，研究突出了其在癌症治疗策略中的潜力（Zhou et al., 2018）。

  • 抗糖尿病活性：来自内生真菌的含脱落酸提取物显示出抗糖尿病活性前景，通过天然产物研究可能增加糖尿病的治疗选择（Uzor et al., 2017）。

  • 葡萄糖耐受性和胰岛素血症的下降：一项突破性的研究发现，水果提取物中微克量的脱落酸显著提高了大鼠和人类的葡萄糖耐受性，降低了胰岛素水平，这表明它可以作为治疗糖尿病的膳食补充剂（Magnone et al., 2015）。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX4704
MKCW0718
WXBF4434V
MKCS8570
MKCR8841

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Scott Hayes et al.
Current biology : CB, 29(10), 1669-1676 (2019-05-06)
Global food production is set to keep increasing despite a predicted decrease in total arable land [1]. To achieve higher production, denser planting will be required on increasingly degraded soils. When grown in dense stands, crops elongate and raise their
Mirko Magnone et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4783-4793 (2015-08-06)
2-Cis,4-trans-abscisic acid (ABA) is a plant hormone that is present also in animals. Several lines of evidence suggest that ABA contributes to the regulation of glycemia in mammals: nanomolar ABA stimulates insulin release from β-pancreatic cells and glucose transporter-4-mediated glucose
Haifeng Jia et al.
The New phytologist, 198(2), 453-465 (2013-02-22)
Fleshy fruits are classically divided into climacteric and nonclimacteric types. It has long been thought that the ripening of climacteric and nonclimacteric fruits is regulated by ethylene and abscisic acid (ABA), respectively. Here, we report that sucrose functions as a
Scott A M McAdam et al.
The New phytologist, 198(2), 429-441 (2013-02-21)
Little is known about how a predominantly passive hydraulic stomatal control in ferns and lycophytes might impact water use under stress. Ferns and lycophytes occupy a diverse array of habitats, from deserts to rainforest canopies, raising the question of whether
Jean-Luc Montillet et al.
PLoS biology, 11(3), e1001513-e1001513 (2013-03-26)
Plant stomata function in innate immunity against bacterial invasion and abscisic acid (ABA) has been suggested to regulate this process. Using genetic, biochemical, and pharmacological approaches, we demonstrate that (i) the Arabidopsis thaliana nine-specific-lipoxygenase encoding gene, LOX1, which is expressed
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Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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