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83060

Sigma-Aldrich

12-氨基-4,7,10-三氧杂十二烷酸叔丁酯

technical, ≥80% (T)

别名:

3-[2-(2-(2-氨基乙氧基)乙氧基)乙氧基]丙酸叔丁酯

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$340.00
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1 G
$340.00
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About This Item

经验公式（希尔记法）:
C13H27NO5
CAS号:
252881-74-6
分子量:
277.36
MDL编号:
MFCD06201017
UNSPSC代码:
12352200
PubChem化学物质编号:
57652942
NACRES:
NA.22

$340.00

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等级

technical

方案

≥80% (T)

表单

solid

反应适用性

reagent type: cross-linking reagent

储存温度

−20°C

SMILES字符串

CC(C)(C)OC(=O)CCOCCOCCOCCN

InChI

1S/C13H27NO5/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h4-11,14H2,1-3H3

InChI key

CWFSAZJIJBTKRC-UHFFFAOYSA-N

相关类别

应用

tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry.[1][2] Some of its applications are:
  • Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.[1]
  • Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.[3]
  • Synthesis of polycationic adamantane-based dendrons for cell imaging.[2]
  • Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).[4]

其他说明

合成组合化学所用间隔臂的中间体[5]

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

337.5 °F

闪点(°C)

169.7 °C

个人防护装备

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCBW2535
BCBM5598V
BCBK2255V
BCBD2137V
BCBB8779

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Towards the Development of Antitumor Vaccines: A Synthetic Conjugate of a Tumor?Associated MUC1 Glycopeptide Antigen and a Tetanus Toxin Epitope.
Keil S, et al.
Angewandte Chemie (International Edition in English), 40(2), 366-369 (2001)
Phthalocyanine?peptide conjugates for epidermal growth factor receptor targeting.
Ongarora B G, et al.
Journal of Medicinal Chemistry, 55(8), 3725-3738 (2012)
Water soluble SERS labels comprising a SAM with dual spacers for controlled bioconjugation.
Jehn C, et al.
Physical Chemistry Chemical Physics, 11(34), 7499-7504 (2009)
Polycationic adamantane-based dendrons of different generations display high cellular uptake without triggering cytotoxicity.
Grillaud M, et al.
Journal of the American Chemical Society, 136(2), 810-819 (2014)
Angewandte Chemie (International Edition in English), 113, 379-379 (2001)

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