803618
DTME (dithio-bis-maleimidoethane)
别名:
1,1′-(dithiodi-2,1-ethanediyl)bis-1H-Pyrrole-2,5-dione, 1-[2-[[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]dithio]ethyl]-1H-pyrrole-2,5-dione, DTME
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About This Item
经验公式（希尔记法）:
C12H12N2S2O4
CAS号:
分子量:
312.36
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.22
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方案
≥90%
表单
powder
分子量
312.37
反应适用性
reagent type: cross-linking reagent
储存条件
desiccated
溶解性
DMSO or DMF: soluble
运输
ambient
储存温度
2-8°C
SMILES字符串
O=C(C=CC1=O)N1CCSSCCN2C(C=CC2=O)=O
InChI
1S/C12H12N2O4S2/c15-9-1-2-10(16)13(9)5-7-19-20-8-6-14-11(17)3-4-12(14)18/h1-4H,5-8H2
InChI key
SGVWDRVQIYUSRA-UHFFFAOYSA-N
一般描述
DTME is a homobifunctional, maleimide crosslinker for conjugation between sulfhydryl groups (-SH). Such bismaleimide crosslinkers are commonly used to explore and characterize protein structure (i.e., oligomerization) or protein interactions. DTME is similar in length to BMH but differs in containing a disulfide bond in its spacer arm, allowing crosslinks with DTME to be cleaved with reducing agent such as dithiothreitol (DTT).
特点和优势
- Reactive groups: maleimide (both ends)
- Reactive towards: sulfhydryl groups
- Long (13.3A), cleavable, sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 11-atom disulfide spacer arm
- Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers
- Cleavable by reduction of disulfide spacer arm with DTT, TCEP or other reducing agent
注意
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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