The weight of each individual gold nanoparticle in this product is approximately 1.02E-17 g. For 10nm particles, it is recommended to use a 100 kDa MWCO Centrifugal Filter or a 30 to 100 kDa NMWL Ultrafiltration Disc.
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物料
PEG 5000
质量水平
表单
dispersion in H2O
nanoparticles
包装
glass bottle of 1 mL
OD
50
直径
10 nm
pH值（酸碱度）
6.0-8.0 (25 °C)
溶解性
water: miscible
密度
1.00 g/cm3
λmax
520 nm
官能团
amine
储存温度
2-8°C
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一般描述
直径范围为 2-200nm 的金纳米颗粒（AuNP） 在多个领域得到应用。它们具有优异的生物相容性和诱人的物理化学特性。金纳米颗粒上的聚（乙二醇）（PEG）表面涂层有助于减少蛋白质吸附，减少与细胞的非特异性相互作用，并大幅改善这些纳米颗粒的药代动力学并减少纳米颗粒的聚集。PEG层密度与AuNP曲率成反比。较小的 AuNP 上可以实现更致密的涂层。涂有 PEG 5000 的 AuNP具有最高的胶体稳定性。以聚乙二醇 （PEG） 为配体或载体分子的胺基功能化 GNP 与 siRNA 形成偶联物，在 RNAi 技术中非常有用。由于粘附在细胞膜上，因此它可用于靶向药物递送应用中的细胞和细胞内靶向，也可用于生物分布研究。[1][2][3][4]
应用
下面列出了其他几项具体应用：
功能化颗粒已广泛用于研究纳米颗粒的细胞摄取和靶向药物递送。
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.
Sarah D Brown et al.
Journal of the American Chemical Society, 132(13), 4678-4684 (2010-03-17)
The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of
Scott H Brewer et al.
Langmuir : the ACS journal of surfaces and colloids, 21(20), 9303-9307 (2005-09-21)
The interaction of bovine serum albumin (BSA) with gold colloids and surfaces was studied using zeta-potential and quartz crystal microbalance (QCM) measurements, respectively, to determine the surface charge and coverage. The combination of these two measurements suggests that BSA binding
Xiao-Dong Zhang et al.
International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of
Timothy A Larson et al.
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)
商品
The recent emergence of a number of highly functional nanomaterials has enabled new approaches to the understanding, diagnosis, and treatment of cancer.
最近出现的许多高功能纳米材料为癌症的认识、诊断和治疗提供了新的方案。
Biomaterials science integrates smart materials into biological research, requiring a deep understanding of biological systems.
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What is the weight of the individual gold nanoparticles for this product? Also, what membrane pore size is generally used with this product?
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