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702153

Sigma-Aldrich

羟基磷灰石

nanoparticles, dispersion, 10 wt. % in H2O, <200 nm particle size (BET)

别名:

Calcium hydroxide phosphate, Calcium hydroxylapatite, Calcium hydroxyphosphate, Nano hydroxyapatatite, Pentacalcium hydroxide triphosphate

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25 ML
$535.00

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25 ML
$535.00

About This Item

线性分子式:
[Ca5(OH)(PO4)3]x
CAS号:
12167-74-7
分子量:
502.31
MDL编号:
MFCD00010904
UNSPSC代码:
12352302
PubChem化学物质编号:
329762350
NACRES:
NA.23

$535.00

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表单

dispersion
nanoparticles

质量水平

100

包含

≤0.025 wt. % dispersant (non-metal based)

浓度

10 wt. % in H2O

表面积

14.3 m2/g , typical

粒径

<200 nm (BET)

pH值（酸碱度）

4-6

密度

1.038 g/mL at 25 °C

SMILES字符串

[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI

1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10

InChI key

XYJRXVWERLGGKC-UHFFFAOYSA-D

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相关类别

一般描述

羟基磷灰石(HAP)是一种骨传导生物陶瓷材料，它具有独特的性能可以直接与活体组织结合。它可以通过多种技术制备，如溶液-凝胶法、水热法、多重乳化法、仿生沉积法和电沉积法。

应用

羟基磷灰石可被用于：
  • 一种替代骨的植入材料，因为其化学成分与 骨中无机盐成分相似且有骨诱导特性。
  • 基因和药物载体，因为它具有封装能力和 对许多药物、蛋白有亲和力。
  • 对pH响应的微粒乳化剂。

特点和优势

  • 生物相容的
  • 骨传导的
  • 在 胜利条件下稳定
  • 高机械强度高强度

法律信息

Engi-Mat Co.产品。

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCQ7691
MKCS4260
MKCP8250
MKCN6392
MKCL6094

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Martin P Reichhardt et al.
Life science alliance, 3(4) (2020-02-27)
The scavenger receptor cysteine-rich (SRCR) family of proteins comprises more than 20 membrane-associated and secreted molecules. Characterised by the presence of one or more copies of the ∼110 amino-acid SRCR domain, this class of proteins have widespread functions as antimicrobial
Xi Chen et al.
The Journal of biological chemistry, 289(16), 11162-11174 (2014-03-13)
Calcium phosphate precipitates (CPPs) form complexes with DNA, which enter cells via endocytosis. Under this condition CPPs induce autophagy via the canonic autophagy machinery. Here we showed that CPP-induced autophagy was also dependent on endocytosis as the process was significantly
Liam M Grover et al.
Biomaterials, 34(28), 6631-6637 (2013-06-12)
Pyrophosphate ions are both inhibitors of HA formation and substrates for phosphatase enzymes. Unlike polyphosphates their hydrolysis results simultaneously in the complete loss of mineral formation inhibition and a localised elevation in orthophosphate ion concentration. Despite recent advances in our
Ehud Segal et al.
PloS one, 4(4), e5233-e5233 (2009-04-22)
There is an immense clinical need for novel therapeutics for the treatment of angiogenesis-dependent calcified neoplasms such as osteosarcomas and bone metastases. We developed a new therapeutic strategy to target bone metastases and calcified neoplasms using combined polymer-bound angiogenesis inhibitors.
Layal Safa et al.
Biochimie, 103, 80-88 (2014-04-22)
Replication protein A (RPA) is a single-stranded DNA binding protein that plays an essential role in telomere maintenance. RPA binds to and unfolds G-quadruplex (G4) structures formed in telomeric DNA, thus facilitating lagging strand DNA replication and telomerase activity. To
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Nanomaterials for Biomedical Applications

Nanoparticles can be used for applications such as growing cells for tissue engineering, nanocomposites used in orthopedics, and miniaturized sensors for DNA, pathogens, and chemicals.

Questions

  1. What is the dispersant used?

    1 answer

    1. The dispersant used is based on polyphosphoric acid, and approximately 0.25 wt% of hydroxyapatite is used.

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