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表单
solid
旋光性
[α]22/D 282.0°, c = 1 in chloroform
mp
86-94 °C
官能团
amine
SMILES字符串
CN(C)P1Oc2ccc3CCCCc3c2-c4c(O1)ccc5CCCCc45
InChI
1S/C22H26NO2P/c1-23(2)26-24-19-13-11-15-7-3-5-9-17(15)21(19)22-18-10-6-4-8-16(18)12-14-20(22)25-26/h11-14H,3-10H2,1-2H3
InChI key
OIZQADYWBXZQKE-UHFFFAOYSA-N
应用
(11bS)-N,N-dimethyl-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine is a monodentate phosphoramidite (MonoPhos) chiral ligand that can be used:
- In the Cu-catalyzed synthesis of chiral 3-(arylbut-1-yn-1-yl)silane derivatives by reacting N-tosylhydrazones with silyl-substituted alkynes via asymmetric insertion.[1]
- In the Rh-catalyzed asymmetric hydrogenation of R-isopropylcinnamic acid derivative, a key intermediate of renin inhibitor aliskiren.[2]
- In the Rh-catalyzed conjugate addition of arylboronic acids to lactones, enones, and nitroalkenes.[3]
法律信息
经 DSM 授权销售，仅供研究之用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
A mixed-ligand approach enables the asymmetric hydrogenation of an α-isopropylcinnamic acid en route to the renin inhibitor aliskiren
Boogers JAF, et al.
Organic Process Research & Development, 11(3), 585-591 (2007)
Asymmetric Copper-Catalyzed C (sp)-H Bond Insertion of Carbenoids Derived from N-Tosylhydrazones
Osako T, et al.
Synlett, 29(17), 2251-2256 (2018)
Rhodium-catalyzed asymmetric conjugate additions of boronic acids using monodentate phosphoramidite ligands
Boiteau J, et al.
Organic Letters, 5(5), 681-684 (2003)
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