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Merck

524980

Sigma-Aldrich

邻苯二甲酸二丁酯(驱蚊叮)

99%

别名:

DBP, 正丁基邻苯二甲酸酯, 邻苯二甲酸二丁基酯

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About This Item

线性分子式:
C6H4-1,2-[CO2(CH2)3CH3]2
CAS号:
分子量:
278.34
Beilstein:
1914064
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

蒸汽密度

9.6 (vs air)

蒸汽壓力

1 mmHg ( 147 °C)

化驗

99%

形狀

liquid

自燃溫度

756 °F

expl. lim.

0.47 %, 236 °F

雜質

≤0.005% Acidity (as Phthalic acid)
≤0.15% water

顏色

APHA: ≤20

折射率

n20/D 1.492 (lit.)

pH值

7 (20 °C, 10 mg/L)

bp

340 °C (lit.)

mp

−35 °C (lit.)

密度

1.043 g/mL at 25 °C (lit.)

SMILES 字串

CCCCOC(=O)c1ccccc1C(=O)OCCCC

InChI

1S/C16H22O4/c1-3-5-11-19-15(17)13-9-7-8-10-14(13)16(18)20-12-6-4-2/h7-10H,3-6,11-12H2,1-2H3

InChI 密鑰

DOIRQSBPFJWKBE-UHFFFAOYSA-N

基因資訊

mouse ... Esr1(13982)

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一般說明

邻苯二甲酸二丁酯(DBP)最常用作各种家用产品中的增塑剂。在使用或处理这些产品时,它可以浸出和蒸发到环境中。因此,针对其毒性和细胞凋亡效应的研究正在进行。研究还表明,接触高剂量的DBP可能会干扰黄体酮和雌二醇的产生。

應用

增塑剂

象形圖

Health hazardEnvironment

訊號詞

Danger

危險聲明

危險分類

Aquatic Acute 1 - Aquatic Chronic 2 - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

367.7 °F - open cup

閃點(°C)

186.5 °C - open cup

個人防護裝備

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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Dibutyl phthalate (DBP)-induced apoptosis and neurotoxicity are mediated via the aryl hydrocarbon receptor (AhR) but not by estrogen receptor alpha (ER?), estrogen receptor beta (ER?), or peroxisome proliferator-activated receptor gamma (PPAR?) in mouse cortical neurons.
Wojtowicz A
Neurotoxicity Research, 31(1), 77-89 (2017)
Dibutyl phthalate impairs steroidogenesis and a subset of LH-dependent genes in cultured human mural granulosa cell in vitro.
Adir M
Reproductive Toxicology, 69, 13-18 (2017)
Linda V Sinclair et al.
Immunometabolism, 2(4), e200029-e200029 (2020-09-04)
Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose (2-NBDG), a fluorescent analogue of 2-deoxyglucose (2DG), as a substrate
Damien Hunter et al.
International journal of molecular sciences, 22(8) (2021-05-01)
Xenobiotic exposure during pregnancy and lactation has been linked to perinatal changes in male reproductive outcomes and other endocrine parameters. This pilot study wished to assess whether brief maternal exposure of rats to xenobiotics dibutyl phthalate (DBP) or diethylstilbestrol (DES)
Harpreet Bhatia et al.
Aquatic toxicology (Amsterdam, Netherlands), 149, 103-115 (2014-03-01)
Phthalic acid esters (PAEs) are a class of synthetic industrial chemicals commonly found in the aquatic environment worldwide. PAEs have been recognised as anti-androgens in male mammals but little is known about their endocrine disrupting effects in fish. This study

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