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Merck

412562

Sigma-Aldrich

(S)-(-)-二氨基丙烷 二盐酸盐

99%

别名:

(S)-(-)-丙二胺 二盐酸盐, (S)-1,2-丙二胺 二盐酸盐

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1 G
$106.00

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1 G
$106.00

About This Item

线性分子式:
CH3CH(NH2)CH2NH2·2HCl
CAS号:
分子量:
147.05
Beilstein:
5740936
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.22

$106.00


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质量水平

方案

99%

旋光性

[α]22/D −4°, c = 20 in H2O

mp

227-229 °C (lit.)

官能团

amine

SMILES字符串

Cl.Cl.C[C@H](N)CN

InChI

1S/C3H10N2.2ClH/c1-3(5)2-4;;/h3H,2,4-5H2,1H3;2*1H/t3-;;/m0../s1

InChI key

AEIAMRMQKCPGJR-QTNFYWBSSA-N

应用

(S)-(-)-1,2-Diaminopropane dihydrochloride may be used in the preparation of following chiral imidazoline derivatives, which show moderate α-adrenergic blocking activity:
  • (S)-(-)-4-methyl-2-(1-naphthylmethyl)imidazoline hydrochloride[1]
  • (S)-(-)-2-benzyl-4-methylimidazoline picrate[2]
  • (S )-(-)-2-[(2,6-dichlorophenyl)imino]-4-methylimidazolidine hydrochloride[2]

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Optically active derivatives of imidazolines: a-Adrenergic blocking properties.
Hsu FL, et al.
Journal of Medicinal Chemistry, 23(11), 1232-1235 (1980)
Stereochemical studies of adrenergic drugs. Optically active derivatives of imidazolines.
Miller DD, et al.
Journal of Medicinal Chemistry, 19(12), 1382-1384 (1976)
Lorin A Thompson et al.
Bioorganic & medicinal chemistry letters, 21(22), 6909-6915 (2011-10-07)
The synthesis, evaluation, and structure-activity relationships of a set of related constrained diaminopropane inhibitors of BACE-1 are described. The full in vivo profile of an optimized inhibitor in both normal and P-gp deficient mice is compared with data generated in
Keisuke Maruyoshi et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 15(7), 1618-1626 (2009-01-09)
Endogenous polyamines, represented by putrescine, spermidine, and spermine, are known to exert their physiological functions by interacting with polyanionic biomolecules such as DNA, RNA, adenosine triphosphate (ATP), and phospholipids. Very few examples of conformation analysis have been reported for these
S A M Fathi et al.
Journal of hazardous materials, 164(1), 133-137 (2008-09-10)
Bis(5-bromo-2-hydroxybenzaldehyde)-1,2-propanediimine is synthesized by the reaction of 5-bromo-2-hydroxybenzaldehyde and 1,2-diaminopropane in ethanol. This ligand is used as a modifier of octadecyl silica disks for preconcentration of trace amounts of copper(II) ions, followed by nitric acid elution and flame atomic absorption

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