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Merck

359270

Sigma-Aldrich

醇钠

97%

别名:

Sodium 2-methylpropan-2-olate, Sodium t-butoxide, Sodium tert-butanolate, Sodium tert-butylate

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5 G
$64.50
25 G
$68.80
100 G
$90.40
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$396.00
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$686.00

$64.50


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5 G
$64.50
25 G
$68.80
100 G
$90.40
500 G
$396.00
1.5 KG
$686.00

About This Item

线性分子式:
NaOC(CH3)3
CAS号:
分子量:
96.10
Beilstein:
3654215
EC 号:
MDL编号:
UNSPSC代码:
12352107
PubChem化学物质编号:
NACRES:
NA.22

$64.50


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蒸汽压

0.0000026 hPa ( 50 °C)

方案

97%

表单

powder

密度

1,025 g/cm3 at 20 °C

SMILES字符串

[Na+].CC(C)(C)[O-]

InChI

1S/C4H9O.Na/c1-4(2,3)5;/h1-3H3;/q-1;+1

InChI key

MFRIHAYPQRLWNB-UHFFFAOYSA-N

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应用

醇钠可用作安全有效的氢化钠替代物,用于羟乙基腺嘌呤和二乙基p-对甲苯磺酰氧基甲基膦酸酯偶合生成9-[2-(二乙基磷酰甲氧基)乙烷]腺嘌呤(二乙基-PMEA), 这是制备阿德福韦酯的重要中间体。[1]
它还可以用于:
  • 在10-菲咯啉衍生物存在下,辅助卤代芳烃与苯衍生物偶合反应。[2]
  • 可以激活第一副族过渡金属预催化剂。[3]
  • 在一种新型环钯化预催化剂存在下,是芳基氯化物氨基化的一种碱。[4]

象形图

FlameCorrosion

警示用语:

Danger

危险声明

危险分类

Eye Dam. 1 - Flam. Sol. 1 - Self-heat. 1 - Skin Corr. 1B

补充剂危害

储存分类代码

4.2 - Pyrophoric and self-heating hazardous materials

WGK

WGK 1

闪点(°F)

57.2 °F

闪点(°C)

14 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Activation and discovery of earth-abundant metal catalysts using sodium tert-butoxide.
Docherty JH, et al.
Nature Chemistry, 9(6), 595-595 (2017)
tert-Butoxide-mediated arylation of benzene with aryl halides in the presence of a catalytic 1, 10-phenanthroline derivative.
Shirakawa E, et al.
Journal of the American Chemical Society, 132(44), 15537-15539 (2010)
Process optimization in the synthesis of 9-[2-(diethylphosphonomethoxy) ethyl] adenine: replacement of sodium hydride with sodium tert-butoxide as the base for oxygen alkylation.
Yu RH, et al.
Organic Process Research & Development, 3(1), 53-55 (1999)
An air and thermally stable one-component catalyst for the amination of aryl chlorides.
Zim D and Buchwald SL.
Organic Letters, 5(14), 2413-2415 (2003)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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