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形狀
solid
包含
~25% water
mp
153-155 °C (lit.)
SMILES 字串
CNC(=N)N[N+]([O-])=O
InChI
1S/C2H6N4O2/c1-4-2(3)5-6(7)8/h1H3,(H3,3,4,5)
InChI 密鑰
XCXKNNGWSDYMMS-UHFFFAOYSA-N
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一般說明
在黄嘌呤氧化酶系统中，1-甲基-3-硝基-1-亚硝基胍 (MNG) 诱发胃癌的过程中，MNG 作为中间产物生成羟基自由基。美国空军武器实验室已将 MNG 用于爆炸物配方。MNG 是在 H2O2 对 MNNG 的亚硝基氮进行亲核进攻过程中形成的。MNG 是 N -甲基- N′ 的非致癌性类似物-硝基- N -亚硝基胍（直接作用的致癌物）。
應用
1-甲基-3-硝基胍（ N -甲基- N′-硝基胍）用于氯噻尼定半抗原的合成。
訊號詞
Danger
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Sol. 1 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
4.1B - Flammable solid hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
E R Kinkead et al.
Toxicology and industrial health, 9(3), 457-477 (1993-05-01)
Currently, N-methyl-N'-nitroguanidine (MNG) is being considered by the U.S. Air Force Armament Laboratory for use in explosive formulations. A mammalian toxicity profile has been performed which includes the analysis of chemical impurities and an assessment of the potential for the
Tomiko Mikuni et al.
Free radical research, 36(6), 641-647 (2002-08-16)
We have examined the mechanism of 1-methyl-3-nitro-1-nitrosoguanidine (MNNG)-induced gastric cancer with respect to the production of hydroxyl free radical (OH). Nucleophilic attack by H2O2 on the nitroso group of MNNG produces 1-methyl-3-nitroguanidine (MNG) and the intermediate peroxynitric acid (ONOOH), which
Shuji Ohno et al.
Toxicology letters, 322, 32-38 (2020-01-11)
Neonicotinoids (NNs), a widely used class of systemic pesticides, are regarded as exhibiting selective toxicity in insects. However, NNs are suspected of exerting adverse effects on mammals as well, including humans. To date, only adult male animal models have been
A W Hsie et al.
Molecular toxicology, 1(2-3), 217-234 (1987-04-01)
Previously, we have shown that Chinese hamster ovary (CHO) cells are useful for quantifying chemical-induced gene mutations. We have defined the conditions of a Multiplex CHO System which permits determination of mutagen-induced chromosome aberration, and sister chromatid exchange (SCE) in
Akihisa Abe et al.
Microbiological research, 162(2), 130-138 (2006-03-08)
The viable but nonculturable (VBNC) suppression mutant formed platable cells at low temperature stress after inoculation in artificial seawater (ASW). Suppression subtractive hybridization was used to identify differentially expressed genes among cDNAs of the VBNC suppression mutant and the wild-type
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