324906

4,5,6,7-四氢吲哚

98%

• 别名: 2,3-Tetramethylenepyrrole, Cyclohex[b]pyrrole, NSC 122455
• 经验公式（希尔记法）: C₈H₁₁N
• CAS号: 13618-91-2
• 分子量: 121.18
• Beilstein: 108853
• MDL编号: MFCD00012134
• UNSPSC代码: 12352100
• PubChem化学物质编号: 24859477
• NACRES: NA.22

属性

• 质量水平: 100
• 方案: 98%
• 表单: solid
• mp: 53-57 °C (lit.)
• 储存温度: 2-8°C
• SMILES字符串: C1CCc2[nH]ccc2C1
• InChI: 1S/C8H11N/c1-2-4-8-7(3-1)5-6-9-8/h5-6,9H,1-4H2
• InChI key: KQBVVLOYXDVATK-UHFFFAOYSA-N

说明

一般描述

4,5,6,7-Tetrahydroindoles, due to their easy aromatization, are good intermediates to synthesize indoles.[1] 4,5,6,7-Tetrahydroindole on condensation with cyanoacetate leads to 1-ethylthio-2-cyano-4,5,6,7-tetrahydrocyclohexa-[c]-3H-pyrrolizin-3-one.[2]

应用

4,5,6,7-Tetrahydroindole was used as reactant in:

• synthesis of ethyl 3-(4,5,6,7-tetrahydroindol-2-yl)-2-propynoate[1]
• preparation of BODIPY dyes[3]
• N-alkylation with chloromethyloxirane[4]
• preparation of hydroindolepropynoate by chemo- and regioselective solvent-free ethynylation[1]
• palladium- and copper-free cross-coupling of halopropynoates[5]
• preparation of carbonylalkenyl indoles via coupling with dicarbonyl compounds[6]
• 1:2 annelation of 4,5,6,7-tetrahydroindole with 1-benzoyl-2-phenylacetylene[7]

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H315,H319,H335
• 预防措施声明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危险分类: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 靶器官: Respiratory system
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: dust mask type N95 (US), Eyeshields, Gloves