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Merck

252999

Sigma-Aldrich

尼亚酰铵

95%

别名:

N-异烟酰-N′-[β-(N-苄基甲酰氨基)乙基]肼, N-苄基-β-(异烟肼)丙酰胺, 吡啶-4-甲酰 2-[2-(苄基氨基甲酰)乙基]酰肼

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About This Item

经验公式(希尔记法):
C16H18N4O2
CAS号:
分子量:
298.34
Beilstein:
492941
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:

方案

95%

mp

152-154 °C (lit.)

溶解性

methanol: soluble 10 mg/mL, clear, colorless to faintly yellow

官能团

amide
amine
hydrazide
phenyl

SMILES字符串

O=C(CCNNC(=O)c1ccncc1)NCc2ccccc2

InChI

1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)

InChI key

NOIIUHRQUVNIDD-UHFFFAOYSA-N

基因信息

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一般描述

Nialamide is an antidepressant drug and its effect on β-adrenergic receptor-adenylate cyclase system of rat pineal gland has been studied[1]. Antidepressant action of the combination of nialamide and 5-hydroxytryptophan has been evaluated[2].

生化/生理作用

非选择性 MAO-A/B 抑制剂。

象形图

Health hazardExclamation mark

警示用语:

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Jason A Nieuwsma et al.
Annals of internal medicine, 167(10), 725-735 (2017-11-14)
Patients who have had an acute coronary syndrome (ACS) event have an increased risk for depression. To evaluate the diagnostic accuracy of depression screening instruments and to compare safety and effectiveness of depression treatments in adults within 3 months of
T Karhula et al.
Neuroscience letters, 194(1-2), 85-88 (1995-07-14)
Localization of 5-hydroxytryptamine immunoreactivity was studied in the rat coeliac-superior mesenteric ganglion complex and in the porcine superior and inferior mesenteric ganglia by the indirect immunofluorescence technique. In normal rats, only 5-hydroxytryptamine immunoreactive SIF cells were seen in the coeliac-superior
H Leblond et al.
The Journal of physiology, 525 Pt 1, 225-240 (2000-05-16)
Intracellular recording of lumbosacral motoneurones in the decerebrate and partially spinalized cat injected with nialamide and L-dihydroxyphenylalanine (l-DOPA) was used to investigate the interneuronal convergence of two bulbospinal pathways and of the segmental pathways involved with the generation of extensor
[Modulation of transcranial electroanalgesia by effecting the serotoninergic system of the brain].
A B Savchenko et al.
Doklady Akademii nauk, 347(2), 275-277 (1996-03-01)
Subsensitivity of the beta-adrenergic receptor-linked adenylate cyclase system of rat pineal gland following repeated treatment with desmethylimipramine and nialamide.
J A Moyer et al.
Molecular pharmacology, 19(2), 187-193 (1981-03-01)

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