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方案
98%
折射率
n20/D 1.4632 (lit.)
mp
7.5 °C (lit.)
密度
1.294 g/mL at 25 °C (lit.)
SMILES字符串
FC(F)(F)c1ccccc1C#N
InChI
1S/C8H4F3N/c9-8(10,11)7-4-2-1-3-6(7)5-12/h1-4H
InChI key
SOZGHDCEWOLLHV-UHFFFAOYSA-N
一般描述
2-(Trifluoromethyl)benzonitrile reacts with tert-butyl acetate in the presence of sulfuric acid to give the corresponding N-tert-butyl amides.
应用
2-(Trifluoromethyl)benzonitrile was used in the synthesis of symmetrical N,N′-alkylidine bisamides.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 2
闪点(°F)
194.0 °F - closed cup
闪点(°C)
90 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
A convenient and efficient protocol for the synthesis of symmetrical N,N'-alkylidine bisamides by sulfamic acid under solvent-free conditions.
Selvam NP, et al.
Canadian Journal of Chemistry, 86(1), 32-38 (2008)
An efficient method for the conversion of aromatic and aliphatic nitriles to the corresponding N-tert-butyl amides: a modified Ritter reaction.
Reddy KL.
Tetrahedron Letters, 44(7), 1453-1455 (2003)
Megumi Morimoto et al.
PloS one, 12(12), e0189480-e0189480 (2017-12-08)
Sarcopenia and cachexia present characteristic features of a decrease in skeletal muscle mass and strength, anorexia, and lack of motivation. Treatments for these diseases have not yet been established, although selective androgen receptor modulators (SARMs) are considered as therapeutic targets.
Nobuyuki Ishikura et al.
International journal of oncology, 46(4), 1560-1572 (2015-01-31)
Resistance of prostate cancer to castration is currently an unavoidable problem. The major mechanisms underlying such resistance are androgen receptor (AR) overexpression, androgen-independent activation of AR, and AR mutation. To address this problem, we developed an AR pure antagonist, CH5137291
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